The effect of flaxseed on lipid profile in healthy individuals: A systematic review and dose-response meta-analysis of clinical trials

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2024-09-01 DOI:10.1016/j.aimed.2024.08.006

Vahid Monfared , Kiyana Talati Far , Farhad Vahid , Adel Salehian , Faezeh Akbarpoor , Zeinab Nikniaz , Zeinab Faghfoori

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Abstract

Introduction

Findings on the effects of flaxseed on the lipid profile in healthy individuals are conflicting. The current comprehensive systematic review and meta-analysis aimed to summarize available evidence in this regard.

Methods

After a systematic search in the online databases, we included the randomized controlled trials (RCTs) investigating the effect of flaxseed on the lipid profile [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), Apolipoprotein -A (apo-A) and Apolipoprotein -B (apo-B)] in healthy individuals.

Results

Altogether, 16 studies with a total sample size of 1000 were included in the analysis. Combining 17 effect sizes from 16 RCTs, we found a significant lowering effect of flaxseed on serum levels of TG (weighted mean difference (WMD): < 0.001, 95 % CI: −0.05–0.05 mmol/L; p = 0.996), TC (WMD: 0.23 mmol/l; 95 % CI: −0.34 to −0.13; p &l; 0.001), LDL-C (WMD): −0.15 mmol/l; 95 % CI: −0.26 to −0.05; p = 0.003), HDL-C (WMD): −0.05 mmol/l; 95 % CI: −0.09 to −0.02; p = 0.001), apo-A (WMD): 0.16 g/l; 95 % CI: −0.26–0.58; p= 0.465) and apo-B (WMD): −0.06 g/l; 95 % CI: −0.15–0.02; p = 0.131).

Conclusion

The present study demonstrates the beneficial effects of flaxseed on TC, HDL-C, and LDL-C in healthy people.

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亚麻籽对健康人血脂状况的影响：临床试验的系统回顾和剂量反应荟萃分析

导言亚麻籽对健康人血脂状况的影响研究结果相互矛盾。目前的综合系统综述和荟萃分析旨在总结这方面的现有证据。方法在对在线数据库进行系统检索后，我们纳入了研究亚麻籽对健康人血脂状况[总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、载脂蛋白-A（apo-A）和载脂蛋白-B（apo-B）]影响的随机对照试验（RCT）。结果共有 16 项研究纳入分析，样本量共计 1000 个。综合 16 项研究的 17 个效应大小，我们发现亚麻籽对血清中的 TG（加权平均差 (WMD)：< 0.001，95 % CI：-0.05-0.05 mmol/L；p = 0.996）、TC（WMD：0.23 mmol/l；95 % CI：-0.34 至 -0.13；p &l; 0.001）、LDL-C（WMD）有显著的降低作用：低密度脂蛋白胆固醇（WMD）：-0.15 毫摩尔/升；95 % CI：-0.26 至-0.05；p = 0.003），高密度脂蛋白胆固醇（WMD）：-0.05 毫摩尔/升；95 % CI：-0.26 至-0.05；p = 0.003-0.05毫摩尔/升；95 % CI：-0.09至-0.02；p = 0.001），载脂蛋白-A（WMD）：0.16克/升；95 % CI：-0.26至0.58；p= 0.465）和载脂蛋白-B（WMD）：-0.06克/升；95 % CI：-0.26至-0.05；p= 0.003）：-结论本研究表明，亚麻籽对健康人的总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇有益。

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.