Cut-off points of adiposity indices associated with insulin resistance in Brazilian postpubertal adolescents

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Pub Date : 2024-08-14 DOI:10.1016/j.nut.2024.112557

Berilany dos Santos Sena M.Sc. , Maria Izabel Siqueira de Andrade Ph.D. , Juliana Souza Oliveira Ph.D. , Vanessa Sá Leal Ph.D. , Pedro Israel Cabral de Lira Ph.D. , Ilma Kruze Grande de Arruda Ph.D.

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引用次数: 0

Abstract

Objectives

This study aims to establish cut-off points for lipid accumulation product and tri-ponderal mass index to identify insulin resistance (IR) in Brazilian postpubertal adolescents.

Methods

We conducted an analysis of postpubertal adolescents enrolled in the national school-based cross-sectional study of cardiovascular risks in adolescents (ERICA-BRAZIL) from February 2013 to November 2014. IR was defined by homeostatic model assessment index for IR values ≥2.32 for girls and ≥2.87 for boys. The analysis involved calculating the area under receiver operating characteristic curves, sensitivity values, specificity, positive and negative predictive values, and positive and negative likelihood ratios to determine reference values of indices with optimal performance.

Results

The sample was comprised of 14 026 adolescents, with 25.3% (95% confidence intervals: 24.6%–26.1%) exhibiting IR, more prevalent among girls and overweight individuals. The ideal lipid accumulation product cut-off points associated with IR were 13.5 for the total population, 13.8 for male adolescents, and 13.5 for girls. Regarding tri-ponderal mass index, the optimal cut-off values for identifying IR were 14.1, 13.9, and 14.5 kg/m³ in the general sample, boys, and girls, respectively.

Conclusions

This study establishes cut-off points for adiposity indices, demonstrating their effectiveness in screening for IR in postpubertal Brazilian adolescents.

查看原文本刊更多论文

巴西青春期后青少年与胰岛素抵抗相关的脂肪指数临界点

方法我们对 2013 年 2 月至 2014 年 11 月参加全国青少年心血管风险校本横断面研究（ERICA-BRAZIL）的青春期后青少年进行了分析。IR的定义是：女孩的IR值≥2.32，男孩的IR值≥2.87。分析包括计算接收者操作特征曲线下面积、灵敏度值、特异性、阳性和阴性预测值以及阳性和阴性似然比，以确定具有最佳性能的指数参考值。结果样本由 14 026 名青少年组成，25.3%（95% 置信区间：24.6%-26.1%）的青少年表现出 IR，其中女孩和超重者更多。与 IR 相关的理想脂质累积产物临界点分别为：总人口 13.5，男性青少年 13.8，女孩 13.5。结论这项研究确定了脂肪指数的临界点，证明了它们在筛查巴西青春期后青少年的 IR 方面的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.