The efficacy of evening primrose seed oil supplements on ART outcomes: A triple-blinded randomized placebo-controlled clinical trial

IF 1.7 Q2 Medicine
Nahid Sohrabi , Amir Fattahi , Farnaz Oghbaei , Kobra Hamdi , Azizeh Farshbaf-Khalili , Mahnaz Shahnazi
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引用次数: 0

Abstract

Background

Evening primrose oil (EPO) has been extensively documented for its potential benefits in various medical conditions, including gestational diabetes, inflammatory diseases, cyclic breast pain, cancer, premenstrual syndrome, menopausal syndrome, and female reproductive disorders.

Objectives

The aim of this study was to investigate the impact of evening primrose oil (EPO) supplementation on the outcomes of assisted reproductive technology (ART).

Methods

A randomized, triple-blinded, placebo-controlled clinical trial was conducted. A total of 84 infertile women who were candidates for intracytoplasmic sperm injection (ICSI) were randomly assigned to either the EPO supplementation group or the placebo (p) group with a 1:1 ratio. The EPO capsule was given from day 1–2 of the ART cycle at a dosage of 1000 mg every eight hours for two weeks. Finally, the ART outcomes parameters as well as the treatment side effects were evaluated.

Results

The results illustrated no statistically significant disparities between the groups in terms of the number of oocytes retrieved, ovarian sensitivity index (OSI), rate of fertilization, and number and quality of embryos (p>0.05). However, a notably enhanced incidence of pregnancy and implantation rates in the EPO group was observed when compared to the P group (42.9 % vs. 17.4 % and 23±30.5 % vs. 10.87±26 %, respectively). Moreover, none of the patients experienced side effects from the intervention.

Conclusions

EPO consumption for two weeks could improve ART outcomes by increasing implantation and pregnancy rates without significantly affecting the number of mature oocytes, rate of fertilization, and the quantity and quality of embryos. These findings highlight the significance of a maternal preconception diet.

月见草籽油补充剂对 ART 结果的疗效:三重盲法随机安慰剂对照临床试验
背景月见草油(EPO)因其对妊娠糖尿病、炎症性疾病、周期性乳房疼痛、癌症、经前综合征、更年期综合征和女性生殖系统疾病等多种疾病的潜在益处而被广泛报道。方法进行了一项随机、三盲、安慰剂对照临床试验。共有 84 名不孕妇女作为卵胞浆内单精子显微注射(ICSI)的候选者,按 1:1 的比例被随机分配到补充 EPO 组或安慰剂(p)组。在抗逆转录病毒疗法周期的第 1-2 天开始服用 EPO 胶囊,剂量为每 8 小时服用 1000 毫克,连续服用两周。最后,对 ART 的结果参数以及治疗的副作用进行了评估。结果表明,各组在取卵数量、卵巢敏感性指数(OSI)、受精率以及胚胎数量和质量方面没有统计学意义上的显著差异(p>0.05)。不过,与 P 组相比,EPO 组的妊娠率和植入率明显提高(分别为 42.9% 对 17.4%,23±30.5% 对 10.87±26%)。结论服用 EPO 两周可提高植入率和妊娠率,从而改善 ART 的结果,而不会显著影响成熟卵母细胞的数量、受精率以及胚胎的数量和质量。这些研究结果突显了孕产妇孕前饮食的重要性。
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来源期刊
Advances in integrative medicine
Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.20
自引率
11.80%
发文量
0
审稿时长
15 weeks
期刊介绍: Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.
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