An anti-aging vaccine: BCG turns back the clock on remyelination failure

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-09-10 DOI:10.1016/j.immuni.2024.08.001

Janssen M. Kotah, Bart J.L. Eggen

引用次数: 0

Abstract

Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination.

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抗衰老疫苗：卡介苗让再髓鞘化失败的时间倒流

衰老会导致一些疾病的发生或加重，这些疾病贯穿人的一生。在中枢神经系统中，衰老会影响维持和修复髓鞘的能力，而髓鞘能保护轴突并促进神经元信号传导。Tiwari 等人报告了脱髓鞘后小胶质细胞中与衰老相关的转录反应，接种卡介苗后，这种反应可通过表观遗传重塑得到逆转。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.