Neighbor’s feedback helps macrophages learn tolerance in the gut

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-09-10 DOI:10.1016/j.immuni.2024.08.012

Giuseppe Giuliani, Jayajit Das

引用次数: 0

Abstract

Intestinal macrophages play a key role in regulating immune tolerance in the gut. In this issue of Immunity, Mertens et al. uncover a mechanism for the establishment of memory in macrophage tolerance in the gut involving a bistable metabolic switch in macrophages and an intercellular positive feedback between macrophages and intestinal epithelial cells (IECs).

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邻居的反馈有助于巨噬细胞学习肠道耐受性

肠道巨噬细胞在调节肠道免疫耐受方面发挥着关键作用。在本期《免疫》杂志上，Mertens 等人揭示了巨噬细胞在肠道中建立耐受记忆的机制，其中涉及巨噬细胞的双稳态代谢转换以及巨噬细胞和肠上皮细胞（IECs）之间的细胞间正反馈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.