Low detection limit of uric acid based on Prussian blue-enhanced photothermal effect with microfiber knot resonator

IF 3.5 2区物理与天体物理 Q2 PHYSICS, APPLIED

Applied Physics Letters Pub Date : 2024-09-09 DOI:10.1063/5.0224050

Yangyuan Zhang, Yangbo Bai, Yinping Miao, Xuanyi Chen, Zhuoyang Han, Jianquan Yao

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Abstract

The human serum uric acid (UA) level is a crucial indicator for diagnosing dementia in middle-aged and elderly individuals, with decreased levels being expressed in patients. Therefore, developing a high-performance sensor for online uric acid detection is of significant research interest. Herein, a microfiber knot resonator (MKR) sensor for quantitative detection of UA levels is reported. Combining polydimethylsiloxane (PDMS) with an adiabatic MKR, the specificity of UA detection in serum is improved using the photothermal effect of Prussian blue-enhanced uricase reaction. During the sensor operation, UA generates the photothermal effect under 650 nm laser irradiation, causing the PDMS film to expand with heat absorption, thereby shifting the resonance spectrum of the PDMS-MKR sensor. Experimental results demonstrate a sensitivity of 0.0559 nm/(μmol/L) within a UA concentration range of 40–120 μmol/L and a detection limit as low as 0.3578 μmol/L. The proposed sensor shows potential applications in clinical point-of-care early diagnosis and prognosis of dementia due to its specificity, fast detection speed, robustness, and high integration.

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基于普鲁士蓝增强光热效应和超细纤维结谐振器的尿酸低检测限技术

人体血清尿酸（UA）水平是诊断中老年痴呆症的一个重要指标，患者血清尿酸水平降低会表现为痴呆症。因此，开发一种在线检测尿酸的高性能传感器具有重要的研究意义。本文报告了一种用于定量检测尿酸水平的超细纤维结谐振器（MKR）传感器。将聚二甲基硅氧烷（PDMS）与绝热 MKR 相结合，利用普鲁士蓝增强尿酸酶反应的光热效应提高了血清中尿酸检测的特异性。传感器工作时，尿酸在 650 纳米激光照射下产生光热效应，使 PDMS 薄膜吸热膨胀，从而移动 PDMS-MKR 传感器的共振频率。实验结果表明，在 UA 浓度为 40-120 μmol/L 的范围内，灵敏度为 0.0559 nm/（μmol/L），检测限低至 0.3578 μmol/L。该传感器具有特异性强、检测速度快、坚固耐用和集成度高等特点，有望应用于临床护理点早期诊断和痴呆症预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Physics Letters 物理-物理：应用

CiteScore

6.40

自引率

10.00%

发文量

1821

审稿时长

1.6 months

期刊介绍： Applied Physics Letters (APL) features concise, up-to-date reports on significant new findings in applied physics. Emphasizing rapid dissemination of key data and new physical insights, APL offers prompt publication of new experimental and theoretical papers reporting applications of physics phenomena to all branches of science, engineering, and modern technology. In addition to regular articles, the journal also publishes invited Fast Track, Perspectives, and in-depth Editorials which report on cutting-edge areas in applied physics. APL Perspectives are forward-looking invited letters which highlight recent developments or discoveries. Emphasis is placed on very recent developments, potentially disruptive technologies, open questions and possible solutions. They also include a mini-roadmap detailing where the community should direct efforts in order for the phenomena to be viable for application and the challenges associated with meeting that performance threshold. Perspectives are characterized by personal viewpoints and opinions of recognized experts in the field. Fast Track articles are invited original research articles that report results that are particularly novel and important or provide a significant advancement in an emerging field. Because of the urgency and scientific importance of the work, the peer review process is accelerated. If, during the review process, it becomes apparent that the paper does not meet the Fast Track criterion, it is returned to a normal track.

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