Synergistic effects between microplastics and glyphosate on honey bee larvae

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-09-07 DOI:10.1016/j.etap.2024.104550

G.A. Mitton , M. Corona , M. Alburaki , A.E. Iglesias , F. Ramos , G. Fuentes , M.M. Vázquez , F.M. Mitton , P. Chan , SR Ruffinengo , M.D. Maggi

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引用次数: 0

Abstract

Microplastic (MPs) pollution has emerged as a global ecological concern, however, the impact of MPs exposure, particularly in conjunction with other pollutants such as glyphosate (GLY) on honey bee remains unknown. This study investigated the effects of exposure to different concentrations of MPs and their combination with GLY on honey bee larvae development, or during the larvae period, regulation of major detoxification, antioxidant and immune genes, and oxidative stress biomarkers. Results revealed that combined exposure to MPs and GLY decreased larvae survivorship and weight, while exposure to MPs alone showed no significant differences. Both MPs and GLY alone downregulated the defensin-1 gene, but only combined exposure with GLY downregulated the hymenoptaecin gene and increased catalase enzyme activity. The data suggest a synergistic effect of MPs and GLY, leading to immunosuppression and reduced larvae survival and weight. These findings highlight potential risks of two prevalent environmental pollutants on honey bee health.

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微塑料和草甘膦对蜜蜂幼虫的协同效应。

微塑料（MPs）污染已成为全球关注的生态问题，然而，暴露于MPs，特别是与草甘膦（GLY）等其他污染物一起暴露对蜜蜂的影响仍然未知。本研究调查了暴露于不同浓度的MPs及其与GLY的组合对蜜蜂幼虫发育或幼虫期主要解毒、抗氧化和免疫基因的调控以及氧化应激生物标志物的影响。结果显示，同时接触 MPs 和 GLY 会降低幼虫的存活率和体重，而单独接触 MPs 则没有显著差异。单独接触 MPs 和 GLY 都会降低防御素-1 基因，但只有联合接触 GLY 才会降低海门霉素基因并提高过氧化氢酶的活性。这些数据表明，MPs 和 GLY 具有协同作用，可导致免疫抑制，降低幼虫的存活率和体重。这些发现凸显了两种普遍存在的环境污染物对蜜蜂健康的潜在风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.