Prevalence of nonalcoholic fatty liver disease in patients with hepatitis B: A meta-analysis.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

World Journal of Clinical Cases Pub Date : 2024-09-06 DOI:10.12998/wjcc.v12.i25.5749

Li Zhang, Hong-Di Wu, Yuan-Fang Qian, Hong-Yan Xu

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引用次数: 0

Abstract

Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with chronic hepatitis B (CHB) has increased in recent clinical practice; however, the relationship between CHB and hepatic steatosis (HS) remains controversial.

Aim: To shed light on the potential association between NAFLD and hepatitis B virus (HBV) infection.

Methods: We conducted a systematic literature search using multiple databases, including PubMed, the Cochrane Library, Web of Science, and EMBASE, to identify relevant studies. Predefined inclusion criteria were used to determine the eligibility of the studies for further analysis.

Results: Comprehensive meta-analysis software was used for statistical analysis, which covered 20 studies. The results indicated a lower NAFLD susceptibility in HBV-infected individuals (pooled OR = 0.87; 95%CI = 0.69-1.08; I ² = 91.1%), with diabetes (P = 0.015), body mass index (BMI; P = 0.010), and possibly age (P = 0.061) as heterogeneity sources. Of note, in four studies (6197 HBV patients), HBV-infected individuals had a reduced NAFLD risk (OR = 0.68, 95%CI = 0.51-0.89, P = 0.006). A positive link between hyperlipidemia and metabolic syndrome emerged in hepatitis B patients, along with specific biochemical indicators, including BMI, creatinine, uric acid, fasting blood glucose, and homeostasis model assessment of insulin resistance.

Conclusion: HBV infection may provide protection against HS; however, the occurrence of HS in patients with HBV infection is associated with metabolic syndrome and specific biochemical parameters.

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乙型肝炎患者非酒精性脂肪肝的患病率：荟萃分析

背景：非酒精性脂肪肝（NAFLD）在慢性乙型肝炎（CHB）患者中的发病率在最近的临床实践中有所增加；然而，CHB 与肝脂肪变性（HS）之间的关系仍存在争议：我们使用多个数据库（包括 PubMed、Cochrane 图书馆、Web of Science 和 EMBASE）进行了系统性文献检索，以确定相关研究。采用预定义的纳入标准确定研究是否符合进一步分析的条件：使用综合荟萃分析软件进行统计分析，共涉及 20 项研究。结果显示，HBV 感染者的非酒精性脂肪肝易感性较低（汇总 OR = 0.87；95%CI = 0.69-1.08；I 2 = 91.1%），糖尿病（P = 0.015）、体重指数（BMI；P = 0.010）和年龄（P = 0.061）可能是异质性来源。值得注意的是，在四项研究（6197 名 HBV 患者）中，HBV 感染者的非酒精性脂肪肝风险降低（OR = 0.68，95%CI = 0.51-0.89，P = 0.006）。乙肝患者的高脂血症与代谢综合征之间存在正相关，同时还存在特定的生化指标，包括体重指数、肌酐、尿酸、空腹血糖和胰岛素抵抗的稳态模型评估：结论：HBV 感染可预防 HS 的发生；然而，HBV 感染者 HS 的发生与代谢综合征和特定的生化指标有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Clinical Cases Medicine-General Medicine

自引率

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发文量

3384

期刊介绍： The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.