Progression independent of relapse activity can be predicted by passively acquired tapping speed through a smartphone for 1 month: A prospective study.
Juan Luis Chico-Garcia, Raquel Sainz Amo, Enric Monreal, Susana Sainz de la Maza, Fernando Rodriguez Jorge, Jaime Masjuan, Lucienne Costa-Frossard, Luisa María Villar
{"title":"Progression independent of relapse activity can be predicted by passively acquired tapping speed through a smartphone for 1 month: A prospective study.","authors":"Juan Luis Chico-Garcia, Raquel Sainz Amo, Enric Monreal, Susana Sainz de la Maza, Fernando Rodriguez Jorge, Jaime Masjuan, Lucienne Costa-Frossard, Luisa María Villar","doi":"10.1177/13524585241272960","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Tapping speed (TS) correlates with baseline disability scales in people with multiple sclerosis (pwMS).</p><p><strong>Objective: </strong>The study aimed to address if progression independent of relapse activity (PIRA) could be predicted by first-month measurement of TS.</p><p><strong>Methods: </strong>Prospective study including pwMS in one referral MS center. Consecutive patients were included and keys/second (Keys/s) were passively measured each day using an in-house smartphone application for 1 month. Median, mean, and maximum keys/s were obtained. Multivariate logistic regression models (including keys/s, age, sex, and baseline disability scores) were obtained for prediction of a PIRA event after 1 year.</p><p><strong>Results: </strong>Overall, 59 patients were included in the final analysis (64.4% women, median age of 44.5 years). However, 10 patients presented a PIRA event, without differences regarding baseline characteristics between PIRA and no-PIRA groups. PIRA group presented lower median keys/s (2 vs 4 keys/s, <i>p</i> = 0.002) and mean keys/s (2.8 vs 4.6, <i>p</i> = 0.008), while maximum keys/s were similar (<i>p</i> = 0.32). A median ⩽ 3 keys/s was independently associated with PIRA (aOR = 16.8, <i>p</i> = 0.03), as did a mean ⩽ 3.7 keys/s (aOR = 17, <i>p</i> = 0.02). These differences were not detected regarding other variables analyzed.</p><p><strong>Conclusion: </strong>Low median or mean keys/s obtained during initial month of assessment were indicative of a PIRA event within the next year.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple Sclerosis Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13524585241272960","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/9 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Tapping speed (TS) correlates with baseline disability scales in people with multiple sclerosis (pwMS).
Objective: The study aimed to address if progression independent of relapse activity (PIRA) could be predicted by first-month measurement of TS.
Methods: Prospective study including pwMS in one referral MS center. Consecutive patients were included and keys/second (Keys/s) were passively measured each day using an in-house smartphone application for 1 month. Median, mean, and maximum keys/s were obtained. Multivariate logistic regression models (including keys/s, age, sex, and baseline disability scores) were obtained for prediction of a PIRA event after 1 year.
Results: Overall, 59 patients were included in the final analysis (64.4% women, median age of 44.5 years). However, 10 patients presented a PIRA event, without differences regarding baseline characteristics between PIRA and no-PIRA groups. PIRA group presented lower median keys/s (2 vs 4 keys/s, p = 0.002) and mean keys/s (2.8 vs 4.6, p = 0.008), while maximum keys/s were similar (p = 0.32). A median ⩽ 3 keys/s was independently associated with PIRA (aOR = 16.8, p = 0.03), as did a mean ⩽ 3.7 keys/s (aOR = 17, p = 0.02). These differences were not detected regarding other variables analyzed.
Conclusion: Low median or mean keys/s obtained during initial month of assessment were indicative of a PIRA event within the next year.
期刊介绍:
Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system.
The journal for your research in the following areas:
* __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics
* __Epidemology and genetics:__ genetics epigenetics, epidemiology
* __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures
* __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management
Print ISSN: 1352-4585