Periodontitis prevalence and acceleration of biological aging: Insights from NHANES 2009-2014 and Mendelian randomization study.

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontal research Pub Date : 2024-09-09 DOI:10.1111/jre.13345

Lin Song, Yifan Wang, Qiwen Zheng, Wenjing Li

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引用次数: 0

Abstract

Aim: This study aimed to investigate the association of periodontitis with biological aging and to assess potential causality using Mendelian randomization (MR).

Methods: A cross-sectional study with 9558 participants from the National Health and Nutrition Examination Survey (2009-2014) was conducted. Age acceleration (BioAgeAccel and PhenoAgeAccel) was calculated from clinical biomarkers and their discrepancies with chronological age. Two-sample MR analysis was performed using data from a large-scale genome-wide association study and UK Biobank.

Results: Periodontitis was associated with increased biological aging, with 0.57-year (95% CI: 0.28-0.86, p < .001) increases in BioAgeAccel and 0.41-year (95% CI: 0.04-0.78, p = .034) increases in PhenoAgeAccel. Subgroup analysis found significantly stronger associations in males for BioAgeAccele (P_INTERACTION = .006), and pronounced associations in young adults (p_interaction = .023), individuals with normal body mass index (p_interaction = .015), and current smokers (p_interaction = .016) for PehonAgeAccel. MR analysis did not provide strong evidence for a causal effect of periodontitis on biological aging (BioAgeAccel: IVW β = 0.008, 95% CI: -0.018 to 0.034, p = .553 and PhenoAgeAccel: IVW β = 0.016, 95% CI: -0.042 to 0.074, p = .585).

Conclusion: This study identified the association of periodontitis and its severity with accelerated aging, suggesting periodontal health could be a possible method in personalized preventive and therapeutic strategies of biological aging.

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牙周炎的流行与生物衰老的加速：从 2009-2014 年国家健康调查和孟德尔随机研究中获得的启示。

目的：本研究旨在调查牙周炎与生物衰老的关系，并使用孟德尔随机法（MR）评估潜在的因果关系：这项横断面研究有 9558 名参与者参加，他们来自美国国家健康与营养调查（2009-2014 年）。年龄加速度（BioAgeAccel 和 PhenoAgeAccel）是根据临床生物标志物及其与年代年龄的差异计算得出的。利用大规模全基因组关联研究和英国生物库的数据进行了双样本 MR 分析：牙周炎与生物老化程度的增加有关，PehonAgeAccel的相关性为0.57年（95% CI：0.28-0.86，P INTERACTION = .006），与年轻成年人（P INTERACTION = .023）、体重指数正常者（P INTERACTION = .015）和当前吸烟者（P INTERACTION = .016）的相关性明显。磁共振分析没有提供强有力的证据证明牙周炎对生物衰老有因果影响（BioAgeAccel：IVW β = 0.008，95% CI：-0.018 至 0.034，p = .553 和 PhenoAgeAccel：IVW β = 0.016，95% CI：-0.042 至 0.074，p = .585）：本研究发现牙周炎及其严重程度与加速衰老有关，这表明牙周健康可能是生物衰老个性化预防和治疗策略的一种方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of periodontal research 医学-牙科与口腔外科

CiteScore

6.90

自引率

5.70%

发文量

103

审稿时长

6-12 weeks

期刊介绍： The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.