NIRS-IVUS Assessment of OCT-Derived Healed Coronary Plaques.

IF 3 2区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Kosei Terada, Takashi Kubo, Amir Kh M Khalifa, Wei-Ting Wang, Suwako Fujita, Ryan D Madder
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引用次数: 0

Abstract

Aims: Healed plaque (HP) is associated with rapid plaque growth and luminal narrowing. Thin-cap fibroatheroma (TCFA) is recognized as a precursor lesion to plaque rupture. The aim of the present study was to compare the lipid size among optical coherence tomography (OCT)-derived HP, TCFA, and thick-cap fibroatheroma (ThCFA) using near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS).

Methods: The present study included 173 patients with acute myocardial infarction (AMI) who underwent percutaneous coronary intervention. Non-culprit lesions with angiographically intermediate stenosis were assessed by both OCT and NIRS-IVUS.

Results: The frequency of TCFA, HP, and ThCFA was 35 (20%), 53 (30%), and 85 (49%), respectively. Minimum lumen area was not significantly different between TCFA and HP, but was smaller in TCFA and HP than in ThCFA (4.6 [interquartile range {IQR}: 3.5-6.4] mm2 vs. 4.3 [3.4-5.3] mm2 vs. 6.5 [4.8-8.6] mm2, P<0.001). Plaque burden was not significantly different between TCFA and HP, but was larger in TCFA and HP than in ThCFA (72 [IQR: 66-80] % vs. 75 [67-80] % vs. 62 [54-69] %, P<0.001). Maximum lipid core burden index in 4mm (maxLCBI4mm) was largest in TCFA, followed by HP and ThCFA (493 [IQR: 443-606] vs. 446 [347-520] vs. 231 [161-302], P<0.001). The frequency of lipid rich plaque with maxLCBI4mm >400 was highest in TCFA, followed by HP and ThCFA (89% vs. 60% vs. 7%, P<0.001).

Conclusions: Based on NIRS-IVUS findings, non-culprit coronary HP in AMI was associated with vulnerable plaque characteristics, but not as much as TCFA.

对 OCT 导出的愈合冠状动脉斑块进行 NIRS-IVUS 评估。
目的:愈合斑块(HP)与斑块快速生长和管腔狭窄有关。薄帽纤维血管瘤(TCFA)被认为是斑块破裂的前兆病变。本研究旨在使用近红外光谱血管内超声(NIRS-IVUS)比较光学相干断层扫描(OCT)得出的 HP、TCFA 和厚盖纤维斑块(ThCFA)的脂质大小:本研究纳入了173名接受经皮冠状动脉介入治疗的急性心肌梗死(AMI)患者。通过 OCT 和 NIRS-IVUS 对血管造影中度狭窄的非冠状动脉病变进行评估:结果:TCFA、HP 和 ThCFA 的发生率分别为 35(20%)、53(30%)和 85(49%)。TCFA和HP的最小管腔面积无明显差异,但TCFA和HP的最小管腔面积小于ThCFA(4.6 [四分位间范围{IQR}:3.5-6.4] mm2 vs. 4.3 [3.4-5.3] mm2 vs. 6.5 [4.8-8.6] mm2,P<0.001)。TCFA和HP的斑块负荷无明显差异,但TCFA和HP的斑块负荷大于ThCFA(72 [IQR: 66-80] % vs. 75 [67-80] % vs. 62 [54-69] %,P<0.001)。TCFA 的 4mm 最大脂质核心负荷指数(maxLCBI4mm)最大,其次是 HP 和 ThCFA(493 [IQR: 443-606] vs. 446 [347-520] vs. 231 [161-302],P<0.001)。在TCFA中,maxLCBI4mm>400的富脂斑块频率最高,其次是HP和ThCFA(89% vs. 60% vs. 7%,P<0.001):结论:根据 NIRS-IVUS 的研究结果,AMI 非冠状动脉 HP 与易损斑块特征相关,但不如 TCFA 相关。
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来源期刊
CiteScore
6.60
自引率
15.90%
发文量
271
审稿时长
1 months
期刊介绍: JAT publishes articles focused on all aspects of research on atherosclerosis, vascular biology, thrombosis, lipid and metabolism.
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