Maternal Streptococcus agalactiae colonization in Europe: data from the multi-center DEVANI study.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2024-09-08 DOI:10.1007/s15010-024-02380-0

Florens Lohrmann, Androulla Efstratiou, Uffe B Skov Sørensen, Roberta Creti, Antoaneta Decheva, Pavla Křížová, Jana Kozáková, Javier Rodriguez-Granger, Manuel De La Rosa Fraile, Immaculada Margarit, Daniela Rinaudo, Domenico Maione, John Telford, Graziella Orefici, Mogens Kilian, Baharak Afshar, Pierrette Melin, Reinhard Berner, Markus Hufnagel, Mirjam Kunze

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引用次数: 0

Abstract

Introduction: Despite national guidelines and use of intrapartum antibiotic prophylaxis (IAP), Streptococcus agalactiae (group B streptococci (GBS)) is still a leading cause of morbidity and mortality in newborns in Europe and the United States. The European DEVANI (Design of a Vaccine Against Neonatal Infections) program assessed the neonatal GBS infection burden in Europe, the clinical characteristics of colonized women and microbiological data of GBS strains in colonized women and their infants with early-onset disease (EOD).

Methods: Overall, 1083 pregnant women with a GBS-positive culture result from eight European countries were included in the study. Clinical obstetrical information was collected by a standardized questionnaire. GBS strains were characterized by serological and molecular methods.

Results: Among GBS carriers included in this study after testing positive for GBS by vaginal or recto-vaginal sampling, 13.4% had at least one additional obstetrical risk factor for EOD. The five most common capsular types (i.e., Ia, Ib, II, III and V) comprised ~ 93% of GBS carried. Of the colonized women, 77.8% received any IAP, and in 49.5% the IAP was considered appropriate. In our cohort, nine neonates presented with GBS early-onset disease (EOD) with significant regional heterogeneity.

Conclusions: Screening methods and IAP rates need to be harmonized across Europe in order to reduce the rates of EOD. The epidemiological data from eight different European countries provides important information for the development of a successful GBS vaccine.

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欧洲产妇无乳链球菌定植：来自多中心 DEVANI 研究的数据。

导言：尽管制定了国家指南并使用了产前抗生素预防（IAP），但在欧洲和美国，无乳链球菌（B 组链球菌，GBS）仍然是新生儿发病和死亡的主要原因。欧洲 DEVANI（新生儿感染疫苗设计）项目评估了欧洲新生儿 GBS 感染负担、定植妇女的临床特征以及定植妇女及其早发疾病（EOD）婴儿体内 GBS 菌株的微生物学数据：研究共纳入了来自 8 个欧洲国家的 1083 名 GBS 培养阳性孕妇。通过标准化问卷收集了临床产科信息。通过血清学和分子方法对 GBS 菌株进行鉴定：结果：在阴道或直肠阴道采样检测出 GBS 阳性的 GBS 携带者中，有 13.4% 的人至少有一个额外的产科风险因素会导致 EOD。五种最常见的荚膜类型（即 Ia、Ib、II、III 和 V）占 GBS 携带者的 93%。77.8%的定植妇女接受了任何IAP治疗，49.5%的妇女接受了适当的IAP治疗。在我们的队列中，9 名新生儿出现了 GBS 早发性疾病 (EOD)，且地区差异显著：结论：欧洲各国需要统一筛查方法和IAP率，以降低EOD的发病率。来自八个不同欧洲国家的流行病学数据为成功开发 GBS 疫苗提供了重要信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.