The effect of intraperitoneal injection of Glycyrrhizin on central regulation of food intake in broilers injected with LPS.

IF 1.6 3区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

British Poultry Science Pub Date : 2024-09-09 DOI:10.1080/00071668.2024.2396451

A Rahdari, F Hamidi

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引用次数: 0

Abstract

1. Poultry farming faces challenges regarding correct hygiene and nutrition. One of the challenges is gram-negative bacteria that stimulate pro-inflammatory reactions through lipopolysaccharide (LPS) and cause disease and anorexia. Liquorice, a medicinal plant containing glycyrrhizin (Glz; a saponin and emulsifier compound) as its main active ingredient, was injected into broilers to investigate any beneficial effects on feed intake in LPS-injected broilers.2. The study involved three experiments using 72 male broiler chickens in each, to examine the impact of Glz on feed intake, especially when challenged with lipopolysaccharide (LPS) by intra-peritoneal (IP) injection to cause inflammation (n = 24). Experiment 1 was conducted to examine the effects of intraperitoneal injection of Glz (12.5, 25 and 50 mg) on feed intake in chickens. In experiment 2, the effects of intracerebroventricular injections of LPS (6.25, 12.5 and 25 ng) were examined. The third experiment investigated the impact of IP injection of Glz on inflammation induced by LPS.3. Injection of Glz significantly increased feed intake in a dose-dependent manner. Whereas LPS significantly reduced the feed intake in feed-deprived chickens (p < 0.05).4. In conclusion, Glz can neutralise the feed intake reduction caused by inflammation in broilers, highlighting its potential role in modulating feed intake in broilers.

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腹腔注射甘草酸苷对注射 LPS 的肉鸡摄食中枢调节的影响

1.家禽养殖面临着正确卫生和营养方面的挑战。挑战之一是革兰氏阴性细菌，它们通过脂多糖（LPS）刺激促炎反应，导致疾病和厌食。甘草是一种药用植物，其主要活性成分是甘草苷（Glz；一种皂苷和乳化剂化合物），将甘草注射到肉鸡体内，研究甘草苷对注射 LPS 的肉鸡采食量的有益影响。该研究包括三个实验，每个实验使用 72 只雄性肉鸡，研究甘草苷对采食量的影响，尤其是通过腹腔注射（IP）脂多糖（LPS）引起炎症时（n = 24）。实验1旨在研究腹腔注射Glz（12.5、25和50毫克）对鸡采食量的影响。实验二考察了脑室内注射 LPS（6.25、12.5 和 25 毫微克）的影响。第三项实验研究了 IP 注射 Glz 对 LPS 引发的炎症的影响。注射 Glz 能明显提高采食量，且呈剂量依赖性。而 LPS 会明显降低缺食鸡的采食量（p

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来源期刊

British Poultry Science 农林科学-奶制品与动物科学

CiteScore

3.90

自引率

5.00%

发文量

审稿时长

4.5 months

期刊介绍： From its first volume in 1960, British Poultry Science has been a leading international journal for poultry scientists and advisers to the poultry industry throughout the world. Over 60% of the independently refereed papers published originate outside the UK. Most typically they report the results of biological studies with an experimental approach which either make an original contribution to fundamental science or are of obvious application to the industry. Subjects which are covered include: anatomy, embryology, biochemistry, biophysics, physiology, reproduction and genetics, behaviour, microbiology, endocrinology, nutrition, environmental science, food science, feeding stuffs and feeding, management and housing welfare, breeding, hatching, poultry meat and egg yields and quality.Papers that adopt a modelling approach or describe the scientific background to new equipment or apparatus directly relevant to the industry are also published. The journal also features rapid publication of Short Communications. Summaries of papers presented at the Spring Meeting of the UK Branch of the WPSA are published in British Poultry Abstracts .