Ranking of Modifiable Lifestyle Risk Factors for Breast Cancer in Saudi Women: Population Attributable Risk and Nomogram.

IF 3.3 4区 医学 Q2 ONCOLOGY
Breast Cancer : Targets and Therapy Pub Date : 2024-09-02 eCollection Date: 2024-01-01 DOI:10.2147/BCTT.S463193
Rawabi M Alsayer, Edward B De Vol, Amani Almeharish, Areej Alfattani, Alaa J Alghamdi, Luluh Behlal AlBehlal, Shatha Alhaddab, Yasmin Altwaijri
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Abstract

Purpose: Breast cancer is the most common cancer among women in the Saudi Arabia, and over 50% of the cases are detected at a late stage. This study aimed to estimate population attributable risk percentage (PAR%) of modifiable lifestyle risk factors for breast cancer in Saudi Arabia.

Patients and methods: A secondary analysis of previously published papers was performed . Relative risks (RR) and odds ratios (OR) were obtained from published international epidemiological studies, and the prevalence of each risk factor in Saudi Arabia was obtained from various sources (eg, national surveys and published literature) to calculate PAR%. A nomogram was used to visually translate the RRs/ORs and their prevalence into PAR% using a practical tool.

Results: Seven modifiable lifestyle risk factors for breast cancer were identified in Saudi Arabia. The identified risk factors included lack of physical activity (sedentary lifestyle), oral contraception (current use), obesity (postmenopausal), hormone replacement therapy (current use), passive smoking, age at first birth (≥ 35 years), and tobacco smoking (current or daily smoking). The PAR% for these risk factors ranged from 0.5% for tobacco smoking to 23.1% for a lack of physical activity. Few modifiable lifestyle risk factors were excluded from this study, due to limited nor unavailable data in Saudi Arabia (eg, alcohol consumption, breastfeeding patterns and childbearing patterns, obesity according to menopausal status, and night-shift work).

Conclusion: Physical inactivity has the most significant modifiable health impact and is a major risk factor for breast cancer. Removing this risk factor would reduce the prevalence of breast cancer in the Saudi population by 23%. There is an immense need to prioritize cancer control strategies based on local needs, current data on cancer risk factors, and the disease burden.

沙特妇女乳腺癌可改变生活方式风险因素排名:沙特妇女乳腺癌可改变的生活方式风险因素排名:人口归因风险和提名图。
目的:乳腺癌是沙特阿拉伯妇女中最常见的癌症,50%以上的病例在晚期才被发现。本研究旨在估算沙特阿拉伯乳腺癌可改变生活方式风险因素的人口归因风险百分比(PAR%):对以前发表的论文进行了二次分析。从已发表的国际流行病学研究中获得了相对风险(RR)和几率比(OR),并从各种来源(如国家调查和已发表的文献)获得了沙特阿拉伯每个风险因素的患病率,以计算 PAR%。使用一个实用工具,将RRs/ORs及其流行率直观地转化为PAR%:结果:在沙特阿拉伯发现了七种可改变的乳腺癌生活方式风险因素。已确定的风险因素包括缺乏体育锻炼(久坐不动的生活方式)、口服避孕药(目前使用)、肥胖(绝经后)、激素替代疗法(目前使用)、被动吸烟、初产妇年龄(≥ 35 岁)和吸烟(目前或每天吸烟)。这些风险因素的 PAR% 从吸烟的 0.5% 到缺乏体育锻炼的 23.1%。由于沙特阿拉伯的数据有限或无法获得,本研究排除了一些可改变的生活方式风险因素(如饮酒、母乳喂养模式和生育模式、更年期肥胖和夜班工作):结论:缺乏运动对健康的影响最大,是乳腺癌的主要风险因素。消除这一风险因素可将沙特人口的乳腺癌发病率降低 23%。我们亟需根据当地需求、癌症风险因素的现有数据以及疾病负担,确定癌症控制战略的优先次序。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
40
审稿时长
16 weeks
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