Five-Repetition Sit-to-Stand Test as Predictor of Mortality in High Risk COPD Patients

IF 8.7 3区 医学 Q1 RESPIRATORY SYSTEM
Roberto Bernabeu-Mora , Elisa Valera-Novella , Elodia Teresa Bernabeu-Serrano , Juan José Soler-Cataluña , Myriam Calle-Rubio , Francesc Medina-Mirapeix
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Abstract

Objective

To determine if adding performance on the five-repetition sit-to-stand test (5-STS) to chronic obstructive pulmonary disease (COPD) high-risk criteria, proposed by the Spanish COPD guidelines (GesEPOC), affects mortality prognosis.

Methods

Observational study of COPD outpatients involved prospective follow-up for 5 years. Patients were classified based on 5-STS performance and risk criteria proposed by GesEPOC version 2021. Outcome measures were 5-year mortality timing and rate. Kaplan–Meier curves and univariate and multivariate Cox proportional-hazard analyses, analysis of variance, and univariate and multivariate linear and logistic regression models were used.

Results

One hundred and thirty-seven patients were included. Mean age was 66 ± 8.3 years, and 87.6% were men. Of them, 115 (83.9%) were classified as high risk, 43 (34.4%) of whom had poor performance on the 5-STS. Overall mortality at 5 years was 27% and was significantly higher in the high-risk (29.6%) compared with the low-risk (13.6%) group. Among high-risk patients, mortality at 5 years was significantly worse with poor 5-STS performance (60.5%) compared with non-poor performance (11.1%). Poor performance on the 5-STS was independently associated with increased 5-year mortality risk (HR 4.70; 95% CI: 1.96–11.27) in a model adjusted for history of heart disease and dyspnea.

Conclusion

Among high-risk COPD patients, those with poor performance on the 5-STS have a significantly higher mortality at 5 years than those with non-poor 5-STS performance.

Abstract Image

五次重复坐立测试预测慢性阻塞性肺病高危患者的死亡率
目的确定在西班牙慢性阻塞性肺病指南(GesEPOC)提出的慢性阻塞性肺病(COPD)高风险标准中加入五次重复坐立测试(5-STS)是否会影响死亡率预后:方法:对慢性阻塞性肺病门诊患者进行为期 5 年的前瞻性随访观察研究。根据 GesEPOC 2021 版提出的 5-STS 表现和风险标准对患者进行分类。结果指标为5年死亡时间和死亡率。采用卡普兰-梅耶曲线、单变量和多变量考克斯比例危险分析、方差分析、单变量和多变量线性及逻辑回归模型:结果:共纳入 137 名患者。平均年龄为(66±8.3)岁,87.6%为男性。其中 115 人(83.9%)被列为高危人群,43 人(34.4%)在 5-STS 中表现不佳。5年的总死亡率为27%,高风险组(29.6%)明显高于低风险组(13.6%)。在高危患者中,5-STS表现不佳者(60.5%)的5年死亡率明显低于表现不佳者(11.1%)。在对心脏病史和呼吸困难进行调整后的模型中,5-STS表现不佳与5年死亡风险增加有独立关联(HR 4.70;95% CI:1.96-11.27):结论:在高危慢性阻塞性肺病患者中,5-STS表现不佳者的5年死亡率明显高于5-STS表现不佳者。
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来源期刊
Archivos De Bronconeumologia
Archivos De Bronconeumologia Medicine-Pulmonary and Respiratory Medicine
CiteScore
3.50
自引率
17.50%
发文量
330
审稿时长
14 days
期刊介绍: Archivos de Bronconeumologia is a scientific journal that specializes in publishing prospective original research articles focusing on various aspects of respiratory diseases, including epidemiology, pathophysiology, clinical practice, surgery, and basic investigation. Additionally, the journal features other types of articles such as reviews, editorials, special articles of interest to the society and editorial board, scientific letters, letters to the editor, and clinical images. Published monthly, the journal comprises 12 regular issues along with occasional supplements containing articles from different sections. All manuscripts submitted to the journal undergo rigorous evaluation by the editors and are subjected to expert peer review. The editorial team, led by the Editor and/or an Associate Editor, manages the peer-review process. Archivos de Bronconeumologia is published monthly in English, facilitating broad dissemination of the latest research findings in the field.
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