Onset and progression of dental erosion in a mouse model.

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Acta Odontologica Scandinavica Pub Date : 2024-09-09 DOI:10.2340/aos.v83.41193

Julie Marie Haabeth Brox, Amela Tulek, Amer Sehic, Aida Mulic, Tor Paaske Utheim, Qalbi Khan

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引用次数: 0

Abstract

Objective: Purpose of this research was to examine the onset, progression and wear rates of dental erosion in an established mouse model.

Material and methods: Dental erosion in mice was experimentally induced, and the acidic effects of cola drink on their teeth after 2, 4 and 6-weeks were closely analysed by scanning electron microscopy. The tooth height and enamel or dentin loss were established. Results: The dental erosion on the molars showed clear progression from 2 to 6 weeks. By the 2-week mark, a significant portion of enamel was already eroded, revealing the dentin on the lingual cusps. When adjusted for attritional wear, molars exposed to cola for 2 weeks showed a 35% drop in lingual tooth height compared to controls (533 μm vs. 818 μm). At 4 and 6 weeks, the cola-exposed group continued to display decreased lingual tooth heights by 40% (476 μm vs. 799 μm) and 43% (440 μm vs. 767 μm), respectively.

Conclusion: This study revealed significant acidic effects of cola drink on mouse molars as early as 2 weeks. These findings highlight the challenge of monitoring dental erosion clinically and underscore the importance of early preventive and intervention measures.

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小鼠模型中牙齿腐蚀的发生和发展。

研究目的本研究的目的是在已建立的小鼠模型中研究牙齿腐蚀的发生、发展和磨损率：材料：实验诱导小鼠牙齿腐蚀，并通过扫描电子显微镜密切分析 2、4 和 6 周后可乐饮料对小鼠牙齿的酸性影响。确定牙齿高度和釉质或牙本质损失。结果显示从 2 周到 6 周，臼齿上的牙齿侵蚀明显加剧。到两周时，相当一部分牙釉质已经被侵蚀，露出了舌尖上的牙本质。根据磨损情况进行调整后，与对照组相比，接触可乐 2 周的臼齿的舌侧牙齿高度下降了 35%（533 μm 对 818 μm）。在 4 周和 6 周时，暴露于可乐的组的舌侧牙齿高度继续下降，降幅分别为 40% （476 μm 对 799 μm）和 43% （440 μm 对 767 μm）：这项研究表明，可乐饮料早在 2 周前就对小鼠臼齿产生了明显的酸性影响。这些发现凸显了临床监测牙齿侵蚀所面临的挑战，并强调了早期预防和干预措施的重要性。

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来源期刊

Acta Odontologica Scandinavica 医学-牙科与口腔外科

CiteScore

4.00

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Odontologica Scandinavica publishes papers conveying new knowledge within all areas of oral health and disease sciences.