Development of Graphene-Based Materials with the Targeted Action for Cancer Theranostics

IF 2.3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Konstantin N. Semenov, Olga S. Shemchuk, Sergei V. Ageev, Pavel A. Andoskin, Gleb O. Iurev, Igor V. Murin, Pavel K. Kozhukhov, Dmitriy N. Maystrenko, Oleg E. Molchanov, Dilafruz K. Kholmurodova, Jasur A. Rizaev, Vladimir V. Sharoyko
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引用次数: 0

Abstract

The review summarises the prospects in the application of graphene and graphene-based nanomaterials (GBNs) in nanomedicine, including drug delivery, photothermal and photodynamic therapy, and theranostics in cancer treatment. The application of GBNs in various areas of science and medicine is due to the unique properties of graphene allowing the development of novel ground-breaking biomedical applications. The review describes current approaches to the production of new targeting graphene-based biomedical agents for the chemotherapy, photothermal therapy, and photodynamic therapy of tumors. Analysis of publications and FDA databases showed that despite numerous clinical studies of graphene-based materials conducted worldwide, there is a lack of information on the clinical trials on the use of graphene-based conjugates for the targeted drug delivery and diagnostics. The review will be helpful for researchers working in development of carbon nanostructures, material science, medicinal chemistry, and nanobiomedicine.

Abstract Image

开发具有癌症治疗靶向作用的石墨烯基材料。
这篇综述总结了石墨烯和石墨烯基纳米材料(GBNs)在纳米医学中的应用前景,包括药物输送、光热和光动力疗法以及癌症治疗中的治疗学。GBNs 在科学和医学各个领域的应用是由于石墨烯的独特性质,它允许开发新的突破性生物医学应用。这篇综述介绍了目前生产新型靶向石墨烯基生物药剂的方法,这些药剂可用于肿瘤的化疗、光热疗法和光动力疗法。对出版物和 FDA 数据库的分析表明,尽管全球范围内对石墨烯基材料进行了大量临床研究,但缺乏将石墨烯基共轭物用于靶向给药和诊断的临床试验信息。这篇综述将对从事碳纳米结构开发、材料科学、药物化学和纳米生物医学的研究人员有所帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochemistry (Moscow)
Biochemistry (Moscow) 生物-生化与分子生物学
CiteScore
4.70
自引率
3.60%
发文量
139
审稿时长
2 months
期刊介绍: Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).
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