4D printing and optimization of biocompatible poly lactic acid/poly methyl methacrylate blends for enhanced shape memory and mechanical properties

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-04 DOI:10.1016/j.jmbbm.2024.106719

Hossein Doostmohammadi , Kamyab Kashmarizad , Majid Baniassadi , Mahdi Bodaghi , Mostafa Baghani

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引用次数: 0

Abstract

This study introduces a novel approach to 4D printing of biocompatible Poly lactic acid (PLA)/poly methyl methacrylate (PMMA) blends using Artificial Neural Network (ANN) and Response Surface Methodology (RSM). The goal is to optimize PMMA content, nozzle temperature, raster angle, and printing speed to enhance shape memory properties and mechanical strength. The materials, PLA and PMMA, are melt-blended and 4D printed using a pellet-based 3D printer. Differential Scanning Calorimetry (DSC) and Dynamic Mechanical Thermal Analysis (DMTA) assess the thermal behavior and compatibility of the blends. The ANN model demonstrates superior prediction accuracy and generalization capability compared to the RSM model. Experimental results show a shape recovery ratio of 100% and an ultimate tensile strength of 65.2 MPa, significantly higher than pure PLA. A bio-screw, 4D printed with optimized parameters, demonstrates excellent mechanical properties and shape memory behavior, suitable for biomedical applications such as orthopaedics and dental implants. This research presents an innovative method for 4D printing PLA/PMMA blends, highlighting their potential in creating advanced, high-performance biocompatible materials for medical use.

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4D 打印和优化生物相容性聚乳酸/聚甲基丙烯酸甲酯共混物，增强形状记忆和机械性能

本研究介绍了一种利用人工神经网络（ANN）和响应面方法（RSM）对生物相容性聚乳酸（PLA）/聚甲基丙烯酸甲酯（PMMA）混合物进行 4D 印刷的新方法。目标是优化 PMMA 含量、喷嘴温度、光栅角度和打印速度，以增强形状记忆特性和机械强度。聚乳酸（PLA）和聚甲基丙烯酸甲酯（PMMA）材料经熔融混合后，使用基于颗粒的三维打印机进行 4D 打印。差示扫描量热法（DSC）和动态机械热分析法（DMTA）评估了混合物的热行为和兼容性。与 RSM 模型相比，ANN 模型显示出更高的预测精度和概括能力。实验结果表明，形状恢复率为 100%，极限拉伸强度为 65.2 兆帕，明显高于纯聚乳酸。采用优化参数进行 4D 打印的生物螺杆具有优异的机械性能和形状记忆特性，适用于骨科和牙科植入物等生物医学应用。这项研究提出了一种 4D 打印聚乳酸/PMMA 混合物的创新方法，凸显了其在制造先进、高性能生物兼容医用材料方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.