Gold nanoparticles antibacterial activity: Does the surface matter?

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications Pub Date : 2024-09-01 DOI:10.1016/j.colcom.2024.100804

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Abstract

The misuse and overuse of antibiotics have ushered in the rapid rise of antimicrobial resistance (AMR). Gold nanoparticles (AuNPs) are considered a potential solution for AMR due to their dual role as antibacterial agents and antibiotic-delivery vehicles. AuNPs with varied surface area, charge, and morphology have been utilized alone and with antibiotics tailored on their surface to overcome resistant bacteria. However, transitioning AuNPs from lab to bedside faces challenges due to the inconsistent antibacterial outcomes and the need for a consensus on the optimal AuNP features that harness their potential as antibacterial agents. This review navigates through the interplay of AuNPs' surface and their antibacterial behavior, considering their surface charge, surface potential, surface coating, surface area, morphology, and antibiotic functionalization. Our review serves as a guide for AuNPs surface features that elicit the most favorable antibacterial outcomes, which will aid in formulating a novel antibacterial agent capable of counteracting AMR.

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金纳米粒子的抗菌活性：表面重要吗？

抗生素的滥用和过度使用导致抗菌药耐药性（AMR）迅速上升。由于金纳米粒子（AuNPs）具有抗菌剂和抗生素输送载体的双重作用，因此被认为是解决 AMR 的潜在方法。具有不同表面积、电荷和形态的 AuNPs 已被单独使用或与表面定制的抗生素一起使用，以战胜耐药细菌。然而，由于抗菌效果不一致，而且需要就利用 AuNP 作为抗菌剂的潜力的最佳 AuNP 特性达成共识，因此将 AuNP 从实验室过渡到临床应用面临着挑战。本综述探讨了 AuNPs 表面与其抗菌行为之间的相互作用，考虑了 AuNPs 的表面电荷、表面电位、表面涂层、表面积、形态和抗生素功能化。我们的综述将指导您了解能产生最有利抗菌效果的 AuNPs 表面特征，这将有助于配制出能对抗 AMR 的新型抗菌剂。

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来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.