{"title":"Risk factors for Helicobacter pylori infection in children with gastrointestinal symptoms in Vietnam","authors":"","doi":"10.1016/j.ijregi.2024.100426","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>To investigate the prevalence and risk factors associated with <em>Helicobacter pylori</em> infection in Vietnamese children.</p></div><div><h3>Methods</h3><p>Children under 16 years old with gastrointestinal symptoms underwent esophagogastroduodenoscopy and <em>H. pylori</em> infection was diagnosed using rapid urease test.</p></div><div><h3>Results</h3><p>A total of 246 children with gastrointestinal symptoms were included. The mean age was 8.4 ± 2.6 years. A total 81.3% tested positive for <em>H. pylori.</em> Children infected with <em>H. pylori</em> had a lower rate of nausea but a higher rate of lesions in the duodenal bulb and nodular lesions than children without <em>H. pylori</em> infection (26.5% vs 45.6%, <em>P</em> <0.01; 40.0% vs 23.9%; <em>P</em> = 0.04; and 68.5% vs 30.3%, <em>P</em> <0.0001, respectively). Compared with children aged under 5 years, children aged 11 years and older were four times more likely to be infected with <em>H. pylori</em>, with odds ratio (OR) 3.50, 95% confidence interval (CI) 1.07-11.39, <em>P</em> = 0.04. Washing hands with soap was associated with a reduced risk of <em>H. pylori</em> infection by three times (OR 0.35, 95% CI 0.17-0.69, <em>P</em> = 0.002). Children living in a family where members had a history of <em>H. pylori</em> infection were nine times more likely to be infected with <em>H. pylori</em> (OR 8.87, 95% CI 1.15-68.45, <em>P</em> = 0.04).</p></div><div><h3>Conclusions</h3><p>The prevalence of <em>H. pylori</em> infection in Vietnamese children with gastroenteritis is high. Our results identified several risk factors and emphasize the role of handwashing with soap before eating and after using the toilet in reducing the risk of <em>H. pylori</em> infection in children.</p></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772707624000973/pdfft?md5=25ffa571cb9341410d0294585e89fd6a&pid=1-s2.0-S2772707624000973-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IJID regions","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772707624000973","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives
To investigate the prevalence and risk factors associated with Helicobacter pylori infection in Vietnamese children.
Methods
Children under 16 years old with gastrointestinal symptoms underwent esophagogastroduodenoscopy and H. pylori infection was diagnosed using rapid urease test.
Results
A total of 246 children with gastrointestinal symptoms were included. The mean age was 8.4 ± 2.6 years. A total 81.3% tested positive for H. pylori. Children infected with H. pylori had a lower rate of nausea but a higher rate of lesions in the duodenal bulb and nodular lesions than children without H. pylori infection (26.5% vs 45.6%, P <0.01; 40.0% vs 23.9%; P = 0.04; and 68.5% vs 30.3%, P <0.0001, respectively). Compared with children aged under 5 years, children aged 11 years and older were four times more likely to be infected with H. pylori, with odds ratio (OR) 3.50, 95% confidence interval (CI) 1.07-11.39, P = 0.04. Washing hands with soap was associated with a reduced risk of H. pylori infection by three times (OR 0.35, 95% CI 0.17-0.69, P = 0.002). Children living in a family where members had a history of H. pylori infection were nine times more likely to be infected with H. pylori (OR 8.87, 95% CI 1.15-68.45, P = 0.04).
Conclusions
The prevalence of H. pylori infection in Vietnamese children with gastroenteritis is high. Our results identified several risk factors and emphasize the role of handwashing with soap before eating and after using the toilet in reducing the risk of H. pylori infection in children.
方法 对有胃肠道症状的 16 岁以下儿童进行食管胃十二指肠镜检查,并使用快速尿素酶测试诊断幽门螺杆菌感染。平均年龄为(8.4 ± 2.6)岁。81.3%的儿童幽门螺杆菌检测呈阳性。与未感染幽门螺杆菌的儿童相比,感染幽门螺杆菌的儿童出现恶心的比例较低,但十二指肠球部病变和结节性病变的比例较高(分别为26.5% vs 45.6%, P <0.01;40.0% vs 23.9%; P = 0.04;68.5% vs 30.3%, P <0.0001)。与 5 岁以下儿童相比,11 岁及以上儿童感染幽门螺杆菌的几率要高出四倍,几率比(OR)为 3.50,95% 置信区间(CI)为 1.07-11.39,P = 0.04。用肥皂洗手可将感染幽门螺杆菌的风险降低三倍(OR 0.35,95% CI 0.17-0.69,P = 0.002)。生活在家庭成员有幽门螺杆菌感染史的家庭中的儿童感染幽门螺杆菌的几率是普通儿童的九倍(OR 8.87,95% CI 1.15-68.45,P = 0.04)。我们的研究结果确定了几个风险因素,并强调了饭前便后用肥皂洗手对降低儿童幽门螺杆菌感染风险的作用。