Differential manifestation of type 2 diabetes in Black Africans and White Europeans with recently diagnosed type 2 diabetes: A systematic review

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM
Davis Kibirige , Ronald Olum , Andrew Peter Kyazze , Bethan Morgan , Felix Bongomin , William Lumu , Moffat J. Nyirenda
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引用次数: 0

Abstract

Aims

The clinical manifestation of type 2 diabetes (T2D) varies across populations. We compared the phenotypic characteristics of Black Africans and White Europeans with recently diagnosed T2D to understand the ethnic differences in the manifestation of T2D.

Methods

We searched Medline, EMBASE, CINAHL, Google Scholar, African Index Medicus, and Global Health for studies reporting information on phenotypic characteristics in Black Africans and White Europeans with recently diagnosed T2D.

Results

A total of 28 studies were included in this systematic review (14 studies conducted on 2586 Black Africans in eight countries and 14 studies conducted on 279,621 White Europeans in nine countries). Compared with White Europeans, Black Africans had a lower pooled mean (95 % confidence interval) age (51.5 [48.5–54.4] years vs. 60.2 [57.9–62.6] years), body mass index (27.0 [24.2–29.8] kg/m2 vs. 31.3 [30.5–32.1] kg/m2), and a higher pooled median glycated haemoglobin (9.0 [8.0–10.3]% vs. 7.1 [6.7–7.7]%). Ugandan and Tanzanian participants had lower markers of beta-cell function and insulin resistance when compared with four White European populations.

Conclusion

These findings provide evidence of the ethnic differences in the manifestation of T2D, underscoring the importance of understanding the underlying factors influencing these differences and formulating ethnic-specific approaches for managing and preventing T2D.

新近确诊为 2 型糖尿病的非洲黑人和欧洲白人的 2 型糖尿病表现差异:系统回顾
目的 不同人群 2 型糖尿病(T2D)的临床表现各不相同。方法 我们检索了 Medline、EMBASE、CINAHL、Google Scholar、African Index Medicus 和 Global Health 中有关非洲黑人和欧洲白人新近确诊的 T2D 表型特征的研究。结果 本系统综述共纳入 28 项研究(14 项研究针对 8 个国家的 2586 名非洲黑人,14 项研究针对 9 个国家的 279621 名欧洲白人)。与欧洲白人相比,非洲黑人的总平均年龄(95 % 置信区间)较低(51.5 [48.5-54.4] 岁 vs. 60.2 [57.9-62.6]岁)、体重指数(27.0 [24.2-29.8] kg/m2 vs. 31.3 [30.5-32.1] kg/m2)和汇总糖化血红蛋白中位数(9.0 [8.0-10.3]% vs. 7.1 [6.7-7.7]%)较高。与四个欧洲白人群体相比,乌干达和坦桑尼亚参与者的β细胞功能和胰岛素抵抗指标较低。 结论:这些研究结果证明了T2D表现形式的种族差异,强调了了解影响这些差异的潜在因素并制定针对不同种族的T2D管理和预防方法的重要性。
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来源期刊
CiteScore
22.90
自引率
2.00%
发文量
248
审稿时长
51 days
期刊介绍: Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.
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