Davis Kibirige , Ronald Olum , Andrew Peter Kyazze , Bethan Morgan , Felix Bongomin , William Lumu , Moffat J. Nyirenda
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引用次数: 0
Abstract
Aims
The clinical manifestation of type 2 diabetes (T2D) varies across populations. We compared the phenotypic characteristics of Black Africans and White Europeans with recently diagnosed T2D to understand the ethnic differences in the manifestation of T2D.
Methods
We searched Medline, EMBASE, CINAHL, Google Scholar, African Index Medicus, and Global Health for studies reporting information on phenotypic characteristics in Black Africans and White Europeans with recently diagnosed T2D.
Results
A total of 28 studies were included in this systematic review (14 studies conducted on 2586 Black Africans in eight countries and 14 studies conducted on 279,621 White Europeans in nine countries). Compared with White Europeans, Black Africans had a lower pooled mean (95 % confidence interval) age (51.5 [48.5–54.4] years vs. 60.2 [57.9–62.6] years), body mass index (27.0 [24.2–29.8] kg/m2 vs. 31.3 [30.5–32.1] kg/m2), and a higher pooled median glycated haemoglobin (9.0 [8.0–10.3]% vs. 7.1 [6.7–7.7]%). Ugandan and Tanzanian participants had lower markers of beta-cell function and insulin resistance when compared with four White European populations.
Conclusion
These findings provide evidence of the ethnic differences in the manifestation of T2D, underscoring the importance of understanding the underlying factors influencing these differences and formulating ethnic-specific approaches for managing and preventing T2D.
期刊介绍:
Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care.
Types of Publications:
Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.