18F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol

IF 3.9
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Abstract

Total cholesterol (TC) and the cholesterol oxidation product 27-hydroxycholesterol (27-OHC) are both increased in the elderly. Accumulating evidence has linked 27-OHC to glucose metabolism in the brain, while docosahexaenoic acid (DHA) has been shown to positively regulate the 27-OHC levels. However, it is unclear whether DHA may affect glucose metabolism in the brain by regulating 27-OHC levels. In this study, we hypothesized that DHA supplementation would modulate TC levels and reduce 27-OHC levels, thereby improving brain glucose metabolism in SAMP8 mice. The mice were assigned into the Control group and DHA dietary supplementation group. The study evaluated cholesterol levels, 27-OHC levels, and glucose metabolism in the brain. The results showed that DHA supplementation decreased serum levels of TC, low-density lipoprotein cholesterol (LDL-C), and increased levels of high-density lipoprotein cholesterol (HDL-C); and improved the glucose-corrected standardized uptake value of cortex, hippocampus, and whole brain regions in SAMP8 mice. In conclusion, supplementation of DHA could regulate the cholesterol composition and reduce the level of 27-OHC, thereby improving brain glucose metabolism in SAMP8 mice.

18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描成像显示了二十二碳六烯酸通过降低大脑 27-羟基胆固醇对葡萄糖代谢的保护作用。
老年人的总胆固醇(TC)和胆固醇氧化产物 27-羟基胆固醇(27-OHC)都会升高。越来越多的证据表明,27-OHC 与大脑中的葡萄糖代谢有关,而二十二碳六烯酸(DHA)已被证明能积极调节 27-OHC 的水平。然而,目前还不清楚 DHA 是否会通过调节 27-OHC 水平来影响大脑中的葡萄糖代谢。在本研究中,我们假设补充 DHA 会调节 TC 水平并降低 27-OHC 水平,从而改善 SAMP8 小鼠的脑糖代谢。小鼠被分为对照组和 DHA 膳食补充剂组。研究评估了胆固醇水平、27-OHC 水平和大脑中的葡萄糖代谢。结果显示,补充 DHA 能降低 SAMP8 小鼠血清中胆固醇、低密度脂蛋白胆固醇(LDL-C)的水平,提高高密度脂蛋白胆固醇(HDL-C)的水平,并能改善大脑皮层、海马和整个脑区的葡萄糖校正标准化摄取值。总之,补充 DHA 可以调节胆固醇组成,降低 27-OHC 水平,从而改善 SAMP8 小鼠的脑糖代谢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Experimental gerontology
Experimental gerontology Ageing, Biochemistry, Geriatrics and Gerontology
CiteScore
6.70
自引率
0.00%
发文量
0
审稿时长
66 days
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