Matrisomics: Beyond the extracellular matrix for unveiling tumor microenvironment

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jiwon Hong , Hyo Joon Jin , Mi Ran Choi , Darren Wan-Teck Lim , Jong-Eun Park , You-Sun Kim , Su Bin Lim
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引用次数: 0

Abstract

The matrisome, a group of proteins constituting or interacting with the extracellular matrix (ECM), has garnered attention as a potent regulator of cancer progression. An increasing number of studies have focused on cancer matrisome utilizing diverse -omics approaches. Here, we present diverse patterns of matrisomal populations within cancer tissues, exploring recent -omics studies spanning different ‘-omics’ levels (epigenomics, genomics, transcriptomics, and proteomics), as well as newly developed sequencing techniques such as single-cell RNA sequencing and spatial transcriptomics. Some matrisome genes showed uniform patterns of upregulated or downregulated expression across various cancers, while others displayed different expression patterns according to the cancer types. This matrisomal dysregulation in cancer was further examined according to their originating cell type and spatial location in the tumor tissue. Experimental studies were also collected to demonstrate the identified roles of matrisome genes during cancer progression. Interestingly, many studies on cancer matrisome have suggested matrisome genes as effective biomarkers in cancer research. Although the specific mechanisms and clinical applications of cancer matrisome have not yet been fully elucidated, recent techniques and analyses on cancer matrisomics have emphasized their biological importance in cancer progression and their clinical implications in deciding the efficacy of cancer treatment.

Matrisomics:超越细胞外基质,揭示肿瘤微环境。
基质组(matrisome)是一组构成细胞外基质(ECM)或与之相互作用的蛋白质,作为癌症进展的一个强有力的调控因子而备受关注。越来越多的研究利用不同的组学方法关注癌症基质组。在这里,我们介绍了癌症组织中基质组群体的不同模式,探讨了最近跨越不同 "组学 "水平(表观基因组学、基因组学、转录组学和蛋白质组学)的组学研究,以及新开发的测序技术,如单细胞 RNA 测序和空间转录组学。在各种癌症中,一些基质组基因表现出统一的上调或下调表达模式,而另一些基因则根据癌症类型表现出不同的表达模式。根据这些基因的起源细胞类型和在肿瘤组织中的空间位置,进一步研究了癌症中的基质组失调情况。此外,还收集了一些实验研究,以证明母体基因在癌症进展过程中的作用。有趣的是,许多关于癌症基质组的研究都认为基质组基因是癌症研究中有效的生物标志物。虽然癌症基质组的具体机制和临床应用尚未完全阐明,但最近的癌症基质组学技术和分析强调了它们在癌症进展中的生物学重要性,以及它们在决定癌症治疗效果方面的临床意义。
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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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