Clinical outcome of salvage surgery in patients with recurrent oral cavity cancer: A systematic review and meta-analysis.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-09-07 DOI:10.1002/hed.27928

Oh-Hyeong Lee, Jooin Bang, Geun-Jeon Kim, Dong-Il Sun, Sang-Yeon Kim

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Abstract

This systematic review and meta-analysis investigated the impact of salvage surgery on 5-year overall survival (OS) and prognostic factors in recurrent oral cavity cancer (rOCC) patients. Relevant literature before May 2022 was reviewed, including retrospective cohort studies and observational studies comparing salvage surgery to other treatments. Risk-of-bias assessments were conducted using the Newcastle-Ottawa scale. Statistical and subgroup analyses assessed the impact of salvage surgery on 5-year OS and prognostic factors. 3036 documents were initially retrieved, with 14 retrospective cohort studies (2069 participants) included. Meta-analysis of 5-year OS in salvage surgery patients yielded a rate of 43.0%. Subgroup analysis showed higher OS in Asians (49.9% vs. 36.9%, p = 0.003) and late-relapse (63.8% vs. 30.0%, p = 0.004) groups. Prognostic factors revealed hazards associated with nodal recurrence, extranodal extension, and perineural invasion. Salvage surgery is a viable option for rOCC patients, showing favorable 5-year OS outcomes. Low publication bias enhances study reliability, but its single-arm design limits conclusions on salvage surgery superiority over other treatments.

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复发性口腔癌患者挽救手术的临床疗效：系统回顾和荟萃分析。

这项系统综述和荟萃分析研究了挽救手术对复发性口腔癌（rOCC）患者5年总生存期（OS）的影响以及预后因素。研究人员查阅了2022年5月之前的相关文献，包括回顾性队列研究和比较挽救手术与其他治疗方法的观察性研究。使用纽卡斯尔-渥太华量表进行了偏倚风险评估。统计和亚组分析评估了抢救性手术对5年OS和预后因素的影响。初步检索到3036篇文献，其中包括14项回顾性队列研究（2069名参与者）。对抢救性手术患者的5年生存率进行的元分析结果显示，抢救性手术患者的5年生存率为43.0%。亚组分析显示，亚洲人（49.9% 对 36.9%，P = 0.003）和晚期复发（63.8% 对 30.0%，P = 0.004）组的 OS 较高。预后因素显示，与结节复发、结节外扩展和神经周围侵犯相关的危险因素。抢救性手术是rOCC患者的可行选择，显示出良好的5年OS结果。低发表偏倚提高了研究的可靠性，但其单臂设计限制了抢救性手术优于其他治疗方法的结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.