Unveiling MRI markers for Parkinson’s Disease: GABAergic dysfunction and cortical changes

IF 3.4 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical Pub Date : 2024-01-01 DOI:10.1016/j.nicl.2024.103661

Yuan Tian , Sijia Geng , Tianyi Liu , Qi Wang , Jianxiu Lian , Liangjie Lin , Jiayu Li , Tao Gong , Junhong Duan , Dan Wang , Pengfei Liu

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引用次数: 0

Abstract

Objective

The study aimed to investigate changes in basal levels of the inhibitory γ-aminobutyric acid (GABA) neurotransmitter in the sensorimotor cortex (SMC) and cortical gyrification in patients with Parkinson’s disease (PD), which could further identify potential imaging biomarkers for PD, particularly in patients with early-onset Parkinson’s disease (EOPD).

Method

Fifty patients with PD (EOPD: 10, late-onset Parkinson’s disease [LOPD]: 40) and fifty-two age- and gender-matched healthy controls (HC) underwent GABA-edited 1H MRS of the SMC and high-resolution 3D T1-weighted brain imaging. GABA levels and local gyrification index (LGI) were calculated to assess GABAergic and cortical gyrification deficits in PD.

Result

The Pearson correlation coefficients revealed significant negative associations between eight indicators, including GABA/Cr level and local gyrification index (LGI) of specific cortical regions (precentral, postcentral, entorhinal, superiortemporal, posteriorcingulate, cuneus, and transversetemporal cortex), and the likelihood of Parkinson’s disease (r < -0.4, p < 0.001). Additionally, GABA levels were significantly lower in the SMC region of both EOPD and LOPD patients compared to healthy controls (mean ± SD [u.i.]: EOPD=0.081 ± 0.022 vs. Young-HC=0.112 ± 0.021, p = 0.003; LOPD=0.054 ± 0.024 vs. Old-HC=0.099 ± 0.021, p < 0.001). The logistic regression model was established by using multivariate analysis, identifying two statistically significant indicators: GABA/Cr and LGI of the transversetemporal. The combined model exhibited the highest AUC values in both younger and older populations.

Conclusion

GABAergic dysfunction may play an important role in the pathogenesis of PD patients. Changes in neurotransmitter and morphological may serve as potential markers for the preclinical diagnosis and progression of PD, including EOPD.

Abstract Image

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揭示帕金森病的 MRI 标记：GABA能功能障碍和皮质变化

研究目的该研究旨在调查帕金森病（PD）患者感觉运动皮层（SMC）和皮层回旋中抑制性γ-氨基丁酸（GABA）神经递质基础水平的变化，从而进一步确定帕金森病的潜在影像生物标志物，尤其是早发性帕金森病（EOPD）患者：50名帕金森病患者（早发帕金森病：10名，晚发帕金森病：40名）和52名年龄与性别匹配的健康对照组（HC）接受了GABA编辑的SMC 1H MRS和高分辨率三维T1加权脑成像检查。计算GABA水平和局部回旋指数（LGI）以评估PD的GABA能和皮质回旋缺陷：结果：皮尔逊相关系数显示，特定皮层区域（前中央区、后中央区、内侧区、上颞区、后颞区、楔皮层和横颞皮层）的 GABA/Cr 水平和局部回旋指数（LGI）等八项指标与帕金森病的可能性呈显著负相关（r 结论：GABA 能功能障碍可能与帕金森病的发病机制有关：GABA 能功能障碍可能在帕金森病患者的发病机制中扮演重要角色。神经递质和形态学的变化可作为帕金森病（包括EOPD）临床前诊断和进展的潜在标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.