Quercetin supplementation prevents kidney damage and improves long-term prognosis in hypertensive patients.

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Phytotherapy Research Pub Date : 2024-11-01 Epub Date: 2024-09-07 DOI:10.1002/ptr.8306
Yawei Zheng, Yuan Fang, Li Li, Huihui Wang, Siqi Zhang, Yuan Zhu, Yating Wang, Xianze Meng, Zhen Fang, Yu Luo, Zhuyuan Fang
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Abstract

Quercetin has shown potential antihypertensive-like activities in several studies. The present study aimed to test the effect of quercetin supplementation on kidney damage and long-term prognosis in hypertensive patients. The data of enrolled hypertensive patients were acquired from the NHANES dataset. The flavanol intake data was extracted from the FNDDS flavonoid database. Information regarding mortality was extracted from the NCHS. A total of 5801 hypertensive patients were included in this study. Preliminary analysis found that the total flavanols intake dosage was the independent influence factor of the kidney damage prevalence in hypertension, and it was found that only the quercetin supplementation was the protective factor for kidney damage after stratification analysis. For every 10 mg/d increase in quercetin intake, the kidney damage prevalence decreased by 8% [OR = 0.92, 95% CI: 0.85-0.99, p = 0.032]. The comprehensive analysis results suggested that hypertensive patients in the quercetin-high group had a lower kidney damage prevalence and a higher survival probability than those in the quercetin-low group. The urine microalbumin of hypertensive patients in the quercetin-high group was significantly lower than that of hypertensive patients in the quercetin-low group. In addition, at a median follow-up time of 122 months, the mortality decreased by 9% [HR = 0.91, 95% CI: 0.84-0.99, p = 0.031] for every 10 mg/d increase in quercetin intake. The findings suggested that high quercetin intake was associated with low kidney damage prevalence and high survival probability. Based on the existing evidence, promoting quercetin supplementation as a supplementary treatment for hypertensive patients was warranted.

补充槲皮素可预防高血压患者的肾损伤并改善长期预后。
多项研究表明,槲皮素具有潜在的抗高血压活性。本研究旨在检测补充槲皮素对高血压患者肾脏损伤和长期预后的影响。入组高血压患者的数据来自 NHANES 数据集。黄烷醇摄入量数据来自 FNDDS 类黄酮数据库。有关死亡率的信息来自美国国家卫生与健康调查(NCHS)。本研究共纳入了 5801 名高血压患者。初步分析发现,总黄烷醇摄入量是高血压肾损害发生率的独立影响因素,分层分析后发现,只有补充槲皮素才是肾损害的保护因素。槲皮素摄入量每增加10毫克/天,肾损害发生率降低8% [OR = 0.92, 95% CI: 0.85-0.99, p = 0.032]。综合分析结果表明,与槲皮素低摄入组相比,槲皮素高摄入组高血压患者的肾损害发生率更低,生存概率更高。槲皮素含量高组高血压患者的尿微量白蛋白明显低于槲皮素含量低组高血压患者。此外,中位随访时间为122个月,槲皮素摄入量每增加10毫克/天,死亡率降低9% [HR = 0.91, 95% CI: 0.84-0.99, p = 0.031]。研究结果表明,高槲皮素摄入量与低肾损伤发生率和高存活率相关。基于现有证据,有必要推广将补充槲皮素作为高血压患者的辅助治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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