Effect of body position during weaning from total liquid ventilation in piglets

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-06 DOI:10.1016/j.resp.2024.104338

Alexandru Panaitescu , Christophe Morin , Mouhamed Amin Boudaouara , Sarah-Gabrielle Taillandier-Pensarini , Nathalie Samson , Jean-Paul Praud , Philippe Micheau , Etienne Fortin-Pellerin

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引用次数: 0

Abstract

Objective

To determine if change in body position improves oxygen requirements and respiratory mechanics during the transition from total liquid ventilation (TLV) to gas ventilation.

Methods

Fourteen piglets underwent TLV, followed by a 2-hour weaning period under conventional gas ventilation. Subjects were randomized to the experimental group (Rotating – R), that was in prone position between the 10th and 30th minute of weaning, or to the static control group (Supine – S).

Results

Oxygenation index was lower in the R group at 30 minutes in prone position than that in the S group (1.9 [1.6; 2.8] vs 3.5 [3.1; 5.1], p = 0.001). This difference disappeared when subjects resumed the supine position (4.2 [3.8; 4.7] and 4.7 [3.8; 5.4], p = 0.4, for the R and S groups, respectively). The change in body position did not affect respiratory system compliance or inspiratory capacity.

Conclusion

Prone position improved oxygenation during weaning from TLV. The effect disappeared once piglets returned to the supine position.

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仔猪断奶时全液体通气体位的影响

目的确定在从全液体通气（TLV）过渡到气体通气的过程中，体位的改变是否能改善氧气需求和呼吸力学：方法：14 头仔猪接受全液体通气，然后在常规气体通气下断奶 2 小时。实验对象被随机分为实验组（旋转 - R）和静态对照组（仰卧 - S）：结果：R 组在 30 分钟俯卧位时的氧合指数低于 S 组（1.9 [1.6; 2.8] vs 3.5 [3.1; 5.1], p = 0.001）。当受试者恢复仰卧位时，这一差异消失（R 组和 S 组分别为 4.2 [3.8; 4.7] 和 4.7 [3.8; 5.4]，p = 0.4）。体位的改变并不影响呼吸系统的顺应性或吸气能力：结论：俯卧位可改善 TLV 断奶期间的氧合。结论：俯卧位可改善 TLV 断奶期间的氧合，一旦仔猪恢复仰卧位，这种效果就会消失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.