Effect of body position during weaning from total liquid ventilation in piglets

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2024-09-06 DOI:10.1016/j.resp.2024.104338

Alexandru Panaitescu , Christophe Morin , Mouhamed Amin Boudaouara , Sarah-Gabrielle Taillandier-Pensarini , Nathalie Samson , Jean-Paul Praud , Philippe Micheau , Etienne Fortin-Pellerin

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引用次数: 0

Abstract

Objective

To determine if change in body position improves oxygen requirements and respiratory mechanics during the transition from total liquid ventilation (TLV) to gas ventilation.

Methods

Fourteen piglets underwent TLV, followed by a 2-hour weaning period under conventional gas ventilation. Subjects were randomized to the experimental group (Rotating – R), that was in prone position between the 10th and 30th minute of weaning, or to the static control group (Supine – S).

Results

Oxygenation index was lower in the R group at 30 minutes in prone position than that in the S group (1.9 [1.6; 2.8] vs 3.5 [3.1; 5.1], p = 0.001). This difference disappeared when subjects resumed the supine position (4.2 [3.8; 4.7] and 4.7 [3.8; 5.4], p = 0.4, for the R and S groups, respectively). The change in body position did not affect respiratory system compliance or inspiratory capacity.

Conclusion

Prone position improved oxygenation during weaning from TLV. The effect disappeared once piglets returned to the supine position.

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仔猪断奶时全液体通气体位的影响

目的确定在从全液体通气（TLV）过渡到气体通气的过程中，体位的改变是否能改善氧气需求和呼吸力学：方法：14 头仔猪接受全液体通气，然后在常规气体通气下断奶 2 小时。实验对象被随机分为实验组（旋转 - R）和静态对照组（仰卧 - S）：结果：R 组在 30 分钟俯卧位时的氧合指数低于 S 组（1.9 [1.6; 2.8] vs 3.5 [3.1; 5.1], p = 0.001）。当受试者恢复仰卧位时，这一差异消失（R 组和 S 组分别为 4.2 [3.8; 4.7] 和 4.7 [3.8; 5.4]，p = 0.4）。体位的改变并不影响呼吸系统的顺应性或吸气能力：结论：俯卧位可改善 TLV 断奶期间的氧合。结论：俯卧位可改善 TLV 断奶期间的氧合，一旦仔猪恢复仰卧位，这种效果就会消失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.