Jaroslav A Hubacek, Nadezda Capkova, Martin Bobak, Hynek Pikhart
{"title":"Association between FTO polymorphism and COVID-19 mortality among older adults: a population-based cohort study.","authors":"Jaroslav A Hubacek, Nadezda Capkova, Martin Bobak, Hynek Pikhart","doi":"10.1016/j.ijid.2024.107232","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>COVID-19 caused a global pandemic with millions of deaths. m<sup>6</sup>A RNA demethylase (FTO) and its functional rs17817449 polymorphism is candidate to influence COVID-19 associated mortality, since methylation status of viral nucleic acids is an important factor influencing viral viability.</p><p><strong>Methods: </strong>We tested a population-based cohort of 5,180 subjects (aged 63-87 years in 2020) where 70 persons died from COVID-19 and 341 from other causes during the pandemic period.</p><p><strong>Results: </strong>The frequency of GG homozygotes was higher among those who died from COVID-19 (34 %) than among survivors (19 %) or deaths from other causes (20 %), p < 0.005. After multiple adjustment, GG homozygotes had higher risk of death from COVID-19 with OR = 2.01 (95% CI; 1.19 - 3.41, p < 0.01) compared with carriers of at least one T allele. The FTO polymorphism was not associated with mortality from other causes.</p><p><strong>Conclusions: </strong>Our results suggest that FTO variability is a significant predictor of COVID-19 associated mortality in Caucasians.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ijid.2024.107232","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: COVID-19 caused a global pandemic with millions of deaths. m6A RNA demethylase (FTO) and its functional rs17817449 polymorphism is candidate to influence COVID-19 associated mortality, since methylation status of viral nucleic acids is an important factor influencing viral viability.
Methods: We tested a population-based cohort of 5,180 subjects (aged 63-87 years in 2020) where 70 persons died from COVID-19 and 341 from other causes during the pandemic period.
Results: The frequency of GG homozygotes was higher among those who died from COVID-19 (34 %) than among survivors (19 %) or deaths from other causes (20 %), p < 0.005. After multiple adjustment, GG homozygotes had higher risk of death from COVID-19 with OR = 2.01 (95% CI; 1.19 - 3.41, p < 0.01) compared with carriers of at least one T allele. The FTO polymorphism was not associated with mortality from other causes.
Conclusions: Our results suggest that FTO variability is a significant predictor of COVID-19 associated mortality in Caucasians.
期刊介绍:
International Journal of Infectious Diseases (IJID)
Publisher: International Society for Infectious Diseases
Publication Frequency: Monthly
Type: Peer-reviewed, Open Access
Scope:
Publishes original clinical and laboratory-based research.
Reports clinical trials, reviews, and some case reports.
Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases.
Emphasizes diseases common in under-resourced countries.