Health state utility values of type 2 diabetes mellitus and related complications: a systematic review and meta-regression.

IF 3.2 2区医学 Q1 HEALTH CARE SCIENCES & SERVICES

Health and Quality of Life Outcomes Pub Date : 2024-09-07 DOI:10.1186/s12955-024-02288-1

Yubo Wang, Yueru Xu, Huiting Shan, Huimin Pan, Ji Chen, Jianhua Yang

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引用次数: 0

Abstract

Background: This study aimed to synthesize and quantitatively examine Health State Utility Values (HSUVs) for Type 2 Diabetes Mellitus (T2DM) and its complications, providing a robust meta-regression framework for selecting appropriate HSUV estimates.

Method: We conducted a systematic review to extract HSUVs for T2DM and its complications, encompassing various influencing factors. Relevant literature was sourced from a review spanning 2000-2020, supplemented by literature from PubMed, Embase, and the Web of Science (up to March 2024). Multivariate meta-regression was performed to evaluate the impact of measurement tools, tariffs, health status, and clinical and demographic variables on HSUVs.

Results: Our search yielded 118 studies, contributing 1044 HSUVs. The HSUVs for T2DM with complications varied, from 0.65 for cerebrovascular disease to 0.77 for neuropathy. The EQ-5D-3L emerged as the most frequently employed valuation method. HSUV differences across instruments were observed; 15-D had the highest (0.89), while HUI-3 had the lowest (0.70) values. Regression analysis elucidated the significant effects of instrument and tariff choice on HSUVs. Complication-related utility decrement, especially in diabetic foot, was quantified. Age <70 was linked to increased HSUVs, while longer illness duration, hypertension, overweight and obesity correlated with reduced HSUVs.

Conclusion: Accurate HSUVs are vital for the optimization of T2DM management strategies. This study provided a comprehensive data pool for HSUVs selection, and quantified the influence of various factors on HSUVs, informing analysts and policymakers in understanding the utility variations associated with T2DM and its complications.

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2 型糖尿病及相关并发症的健康状态效用值：系统回顾与元回归。

背景：本研究旨在综合并定量研究 2 型糖尿病（T2DM）及其并发症的健康状态效用值（HSUV），为选择合适的 HSUV 估计值提供一个稳健的元回归框架：我们对 T2DM 及其并发症的 HSUV 进行了系统回顾，其中包括各种影响因素。相关文献来源于 2000-2020 年的综述，并以 PubMed、Embase 和 Web of Science（截至 2024 年 3 月）中的文献作为补充。我们进行了多变量元回归，以评估测量工具、关税、健康状况以及临床和人口统计学变量对 HSUVs 的影响：结果：我们的搜索共获得 118 项研究，贡献了 1044 个 HSUVs。T2DM 并发症的 HSUVs 各不相同，从脑血管疾病的 0.65 到神经病变的 0.77。EQ-5D-3L 是最常用的评估方法。不同工具的 HSUV 值存在差异；15-D 的 HSUV 值最高（0.89），而 HUI-3 的 HSUV 值最低（0.70）。回归分析阐明了工具和关税选择对 HSUV 的显著影响。与并发症相关的效用下降也得到了量化，尤其是在糖尿病足方面。年龄结论：准确的 HSUV 对 T2DM 管理策略的优化至关重要。本研究为 HSUVs 的选择提供了一个全面的数据池，并量化了各种因素对 HSUVs 的影响，为分析人员和政策制定者了解 T2DM 及其并发症相关的效用变化提供了信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Health and Quality of Life Outcomes 医学-卫生保健

CiteScore

7.30

自引率

2.80%

发文量

154

审稿时长

3-8 weeks

期刊介绍： Health and Quality of Life Outcomes is an open access, peer-reviewed, journal offering high quality articles, rapid publication and wide diffusion in the public domain. Health and Quality of Life Outcomes considers original manuscripts on the Health-Related Quality of Life (HRQOL) assessment for evaluation of medical and psychosocial interventions. It also considers approaches and studies on psychometric properties of HRQOL and patient reported outcome measures, including cultural validation of instruments if they provide information about the impact of interventions. The journal publishes study protocols and reviews summarising the present state of knowledge concerning a particular aspect of HRQOL and patient reported outcome measures. Reviews should generally follow systematic review methodology. Comments on articles and letters to the editor are welcome.