Quantitative phenotyping of verbal and non-verbal cognitive impairment using diffusion-weighted MRI connectome: Preliminary study of the crowding effect in children with left hemispheric epilepsy

IF 2.3 3区 医学 Q2 BEHAVIORAL SCIENCES
Jeong-Won Jeong , Min-Hee Lee , Michael Behen , Hiroshi Uda , Nore Gjolaj , Aimee Luat , Eishi Asano , Csaba Juhász
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Abstract

The “crowding” effect (CE), wherein verbal functions are preserved presumably at the expense of nonverbal functions, which diminish following inter-hemispheric transfer of language functions, is recognized as a specific aspect of functional reorganization, offering an insight about neural plasticity in children with neural insult to the dominant hemisphere. CE is hypothesized as a marker for language preservation or improvement after left-hemispheric injury, yet it remains challenging to fully discern it in preoperative evaluation. We present a novel DWI connectome (DWIC) approach to predict the presence of CE in 24 drug-resistant epilepsy (DRE) patients with a left-hemispheric focus and 29 young healthy controls. Psychometry-driven DWIC analysis was applied to create verbal and non-verbal modular networks. Local efficiency (LE) was assessed at individual regions of the two networks and its Z-score was compared to predict the presence of CE. Compared with a traditional organization (TO) group, wherein verbal functions are adversely affected, while non-verbal functions are preserved, the CE group showed significantly higher Z-scores in verbal network and significantly lower Z-scores in non-verbal network, corresponding to network reorganization in CE. A larger number of antiseizure drugs was significantly associated with more decreased Z-score in the right non-verbal network of the CE group and left verbal network of the TO group. These findings hold great potential to identify DRE patients whose verbal/language skills may over time be preserved due to effective inter-hemispheric reorganization and identify those whose verbal/language impairments may persist due to lack of inter-hemispheric reorganization.

利用弥散加权磁共振成像连接组对语言和非语言认知障碍进行定量表型:左半球癫痫患儿拥挤效应的初步研究。
"拥挤 "效应(CE)是指语言功能的保留可能以牺牲非语言功能为代价,而非语言功能则会在语言功能的半球间转移后减弱,这种效应被认为是功能重组的一个特定方面,为优势半球受到神经损伤的儿童的神经可塑性提供了启示。CE被假定为左半球损伤后语言保留或改善的标志,然而在术前评估中要完全辨别CE仍具有挑战性。我们介绍了一种新颖的 DWI 连接组(DWIC)方法,用于预测 24 名左侧大脑半球病灶的耐药性癫痫(DRE)患者和 29 名年轻健康对照者是否存在 CE。心理测量驱动的 DWIC 分析用于创建语言和非语言模块网络。在这两个网络的个别区域对局部效率(LE)进行评估,并比较其Z-分数,以预测是否存在CE。传统组织(TO)组的言语功能受到不利影响,而非言语功能则得以保留,与之相比,CE 组的言语网络 Z 值明显较高,而非言语网络 Z 值则明显较低,这与 CE 组的网络重组相对应。服用抗癫痫药物的次数越多,CE 组右侧非言语网络和 TO 组左侧言语网络的 Z 评分下降越多。这些发现具有很大的潜力,可用于识别那些因大脑半球间有效重组而使言语/语言能力随着时间的推移得以保留的聋儿,以及识别那些因缺乏大脑半球间重组而使言语/语言障碍持续存在的聋儿。
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来源期刊
Epilepsy & Behavior
Epilepsy & Behavior 医学-行为科学
CiteScore
5.40
自引率
15.40%
发文量
385
审稿时长
43 days
期刊介绍: Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.
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