Sex-dependent perturbations in risky choice behavior and prefrontal tyrosine hydroxylase levels induced by repetitive mild traumatic brain injury

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES
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引用次数: 0

Abstract

Head trauma often impairs cognitive processes mediated within the prefrontal cortex (PFC), leading to impaired decision making and risk-taking behavior. Mild traumatic brain injury (mTBI) accounts for approximately 80 % of reported head injury cases. Most neurological symptoms of a single mTBI are transient; however, growing evidence suggests that repeated mTBI (rmTBI) results in more severe impairments that worsen with each subsequent injury. Although mTBI-induced disruption of risk/reward decision making has been characterized, the potential for rmTBI to exacerbate these effects and the neural mechanisms involved are unknown. Catecholamine neurotransmitters, dopamine (DA) and norepinephrine (NE), modulate PFC-mediated functions. Imbalances in catecholamine function have been associated with TBI and may underlie aberrant decision making. We used a closed head-controlled cortical impact (CH-CCI) model in rats to evaluate the effects of rmTBI on performance of a probabilistic discounting task of risk/reward decision making behavior and expression levels of catecholamine regulatory proteins within the PFC. RmTBI produced transient increases in risky choice preference in both male and female rats, with these effects persisting longer in females. Additionally, rmTBI increased expression of the catecholamine synthetic enzyme, tyrosine hydroxylase (TH), within the orbitofrontal (OFC) region of the PFC in females only. These results suggest females are more susceptible to rmTBI-induced disruption of risk/reward decision making behavior and dysregulation of catecholamine synthesis within the OFC. Together, using the CH-CCI model of rodent rmTBI to evaluate the effects of multiple insults on risk-taking behavior and PFC catecholamine regulation begins to differentiate how mTBI occurrences affect neuropathological outcomes across different sexes.

重复性轻度脑外伤诱发的危险选择行为和前额叶酪氨酸羟化酶水平的性别依赖性干扰
头部创伤通常会损害前额叶皮质(PFC)介导的认知过程,从而导致决策和冒险行为受损。轻度创伤性脑损伤(mTBI)约占报告的头部创伤病例的 80%。单次轻微创伤性脑损伤引起的神经系统症状大多是短暂的,但越来越多的证据表明,反复轻微创伤性脑损伤(rmTBI)会导致更严重的损伤,而且每次损伤都会加重损伤程度。虽然 mTBI 引起的风险/回报决策紊乱已被证实,但 rmTBI 加剧这些影响的可能性以及相关的神经机制尚不清楚。儿茶酚胺神经递质、多巴胺(DA)和去甲肾上腺素(NE)可调节前脑功能区介导的功能。儿茶酚胺功能失衡与创伤性脑损伤有关,可能是决策失常的基础。我们使用闭头控制的大鼠皮层冲击(CH-CCI)模型来评估 RmTBI 对风险/回报决策行为概率贴现任务的表现以及 PFC 中儿茶酚胺调节蛋白表达水平的影响。RmTBI对雄性和雌性大鼠的风险选择偏好都产生了短暂的增加,这些影响在雌性大鼠中持续的时间更长。此外,只有雌性大鼠的 RmTBI 增加了 PFC 的眶额区儿茶酚胺合成酶--酪氨酸羟化酶(TH)的表达。这些结果表明,女性更容易受到 rmTBI 引起的风险/回报决策行为紊乱和 OFC 内儿茶酚胺合成失调的影响。总之,利用啮齿动物rmTBI的CH-CCI模型来评估多重损伤对冒险行为和PFC儿茶酚胺调节的影响,可以开始区分mTBI的发生如何影响不同性别的神经病理学结果。
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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