Solvent-Controlled Divergent Cyclization of 3-Ylideneoxindoles with Ethyl 2-Diazoacetate: Access to Spirocyclopropyl and Spiropyrazolines Oxindoles.

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2024-09-07 DOI:10.1002/chem.202402654

Ding-Xiong Xie, Yue-Mei Huang, Xiao-Min Lin, Zheng-Hui Kang, Chen-Chen Ni, Yao-Tong Fu, Zhi Ren, Yun-Lin Liu

引用次数: 0

Abstract

Herein a catalyst-free solvent-controlled method for the divergent synthesis of spirocyclopropyl and spiropyrazoline oxindoles from 3-ylideneoxindoles and ethyl diazoacetate was developed. With ClCH2CH2Cl as the solvent, spirocyclopropyl oxindoles were obtained in moderate to excellent yields, whereas the use of MeOH as solvent afforded spiropyrazoline oxindoles in moderate to good yields. The readily available substrates, simple operation and various product transformations further highlighted the utility of this method.

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3-Ylideneoxindoles 与 2-重氮乙酸乙酯的溶剂控制发散环化：获得螺环丙基和螺吡唑啉氧化吲哚。

本文开发了一种无催化剂溶剂控制方法，用于以 3-亚基吲哚和重氮乙酸乙酯为原料，分歧合成螺环丙基和螺并吡唑啉吲哚。以 ClCH2CH2Cl 为溶剂，螺环丙基氧化吲哚的产率为中等到极好，而以 MeOH 为溶剂，螺丙唑啉氧化吲哚的产率为中等到良好。该方法的底物易得、操作简单、产物转化多样，进一步凸显了该方法的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

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