First Results of the 4D-PET Brain System

IF 4.6 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Andrea Gonzalez-Montoro;Santiago Jiménez-Serrano;Jorge Álamo;Julio Barberá;Alejandro Lucero;Neus Cucarella;Karel Díaz;Marta Freire;Antonio J. Gonzalez;Laura Moliner;Álvaro Mondejar;Constantino Morera-Ballester;John Prior;David Sánchez;Jose M. Benlloch
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Abstract

Positron emission tomography (PET) imaging is the molecular technique of choice for studying many illnesses, including the ones related to the brain. Nevertheless, the use of PET scanners in neurology is limited by several factors, such as their limited availability for brain imaging due to the high oncology demand for PET and the low sensitivity and poor spatial resolution in the brain of the standard PET scanners. To expand the PET application in neurology, the brain-specific systems with increased clinical and physical sensitivities and higher spatial resolution are required. The present work reports on the design and development process of a compact dedicated PET scanner suitable for human brain imaging. This article includes the description and experimental validation of the detector components and their implementation in a full-size system called 4D-PET. The detector has been designed to simultaneously provide photon depth of interaction (DOI) and time of flight (TOF) information. It is based on the semi-monolithic LYSO modules optically coupled to silicon photomultipliers (SiPMs) and connected to a multiplexing readout. The analog output signals are fed to the PETsys TOFPET2 analog-specific integrated circuit circuits enabling scalability of the readout. The evaluation of the 4D-PET modules resulted in average detector resolutions of $2.1\pm 1$ .0 mm, $3.4\pm 1$ .8 mm, and $386\pm 9$ ps for the y- (transaxial direction), DOI-, and coincidence time resolution TOF, respectively. The preliminary 4D-PET imaging performance is reported through the simulations and for the first time through the real reconstructed images (collected in the La Fe Hospital, Valencia).
4D-PET 脑系统的首批成果
正电子发射断层扫描(PET)成像是研究许多疾病(包括与脑有关的疾病)的首选分子技术。然而,PET 扫描仪在神经病学中的应用受到几个因素的限制,例如,由于肿瘤学对 PET 的需求很高,因此脑成像的可用性有限,以及标准 PET 扫描仪的灵敏度低、脑部空间分辨率差。为了扩大 PET 在神经学领域的应用,需要临床和物理灵敏度更高和空间分辨率更高的脑部专用系统。本研究报告介绍了适用于人脑成像的紧凑型专用 PET 扫描仪的设计和开发过程。这篇文章包括探测器组件的描述和实验验证,以及它们在名为 4D-PET 的全尺寸系统中的实施情况。探测器的设计目的是同时提供光子相互作用深度(DOI)和飞行时间(TOF)信息。它基于半单片式 LYSO 模块,与硅光电倍增管(SiPM)光学耦合,并连接到多路复用读出器。模拟输出信号被馈送到 PETsys TOFPET2 模拟专用集成电路电路,从而实现了读出的可扩展性。通过对 4D-PET 模块的评估,Y-(横轴方向)、DOI- 和重合时间分辨率 TOF 的平均探测器分辨率分别为 2.1/pm 1$ .0 mm、3.4/pm 1$ .8 mm 和 386/pm 9$ ps。通过模拟和首次通过真实重建图像(在巴伦西亚拉费医院采集)报告了初步的 4D-PET 成像性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
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