Cognitive control: exploring the causal role of the rTPJ in empathy for pain mediated by contextual information.

Helena Hartmann, Egle M Orlando, Karina Borja, Christian Keysers, Valeria Gazzola
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Abstract

Empathy determines our emotional and social lives. Research has recognized the role of the right temporoparietal junction (rTPJ) in social cognition; however, there is less direct causal evidence for its involvement in empathic responses to pain, which is typically attributed to simulation mechanisms. Given the rTPJ's role in processing false beliefs and contextual information during social scenarios, we hypothesized that empathic responses to another person's pain depend on the rTPJ if participants are given information about people's intentions, engaging mentalizing mechanisms alongside simulative ones. Participants viewed videos of an actress freely showing or suppressing pain caused by an electric shock while receiving 6 Hz repetitive transcranial magnetic stimulation (rTMS) over the rTPJ or sham vertex stimulation. Active rTMS had no significant effect on participants' ratings depending on the pain expression, although participants rated the actress's pain as lower during rTPJ perturbation. In contrast, rTMS accelerated response times for providing ratings during pain suppression. We also found that participants perceived the actress's pain as more intense when they knew she would suppress it rather than show it. These results suggest an involvement of the rTPJ in attributing pain to others and provide new insights into people's behavior in judging others' pain when it is concealed.

认知控制:探索 rTPJ 在以情境信息为中介的疼痛移情中的因果作用。
移情决定着我们的情感和社会生活。研究已经认识到右侧颞顶叶交界处(rTPJ)在社会认知中的作用,但关于它参与对疼痛的共情反应的直接因果证据却较少,而这种共情反应通常归因于模拟机制。鉴于rTPJ在社会情景中的虚假信念和上下文信息中的作用,我们假设,如果参与者获得了有关人们意图的信息,那么对他人疼痛的移情反应就会依赖于rTPJ,从而使心智化机制与模拟机制同时发挥作用。参与者在观看女演员自由显示或抑制电击造成的疼痛的视频时,会接受6赫兹重复经颅磁刺激(rTMS),刺激rTPJ或假性顶点。主动经颅磁刺激对参与者的评分没有明显影响,取决于疼痛的表现形式,尽管参与者在经颅磁刺激扰动时对女演员的疼痛评分较低。相反,经颅磁刺激加快了疼痛抑制时提供评分的反应时间。我们还发现,当参与者知道女演员会抑制疼痛而不是表现疼痛时,他们会认为女演员的疼痛更强烈。这些结果表明,rTPJ 参与了将疼痛归因于他人的过程,并为人们在判断他人隐藏的疼痛时的行为提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
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