Increased Risk of Short-Term Infection After Liver Transplantation Combined With Splenectomy: Clinical Retrospective Study

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2024-09-04 DOI:10.1016/j.transproceed.2024.08.043

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引用次数: 0

Abstract

Aim

The safety of liver transplantation and simultaneous splenectomy (LTSP) is still controversial. This study aimed to compare postoperative outcomes and infection in liver transplant recipients with and without simultaneous splenectomy.

Methods

Clinical data of patients who underwent liver transplantation (LT) from May 2015 to March 2023 in the First Affiliated Hospital of Anhui Medical University were retrospectively analyzed. The main parameters measured were culture results, infection incidence, pathogens, postoperative complications, and overall survival rates.

Results

Of 149 patients, 35 who underwent LTSP were assigned to the LTSP group, and the remaining 114 were assigned to the LT group. The postoperative infection incidence in the LTSP group was significantly higher than in the LT group within 1 month after transplantation. The two groups had no significant differences in pathogens details and overall survival rate. SP, postoperative days (POD) 3 Neutrophil to lymphocyte ratio (NLR), POD 7 NLR, and POD 7 Hemoglobin (HGB) were independent risk factors for postoperative infection in multivariate analysis.

Conclusion

LTSP increases the risk of short-term postoperative infections, and postoperative NLR can be used as a marker of infection.

查看原文本刊更多论文

肝移植合并脾切除术后短期感染风险增加：临床回顾性研究

目的：肝移植同时进行脾切除术（LTSP）的安全性仍存在争议。本研究旨在比较肝移植受者术后结果和感染情况，包括是否同时进行脾脏切除术：方法：回顾性分析安徽医科大学第一附属医院 2015 年 5 月至 2023 年 3 月期间接受肝移植手术（LT）患者的临床数据。测量的主要参数包括培养结果、感染发生率、病原体、术后并发症和总生存率：149例患者中，35例接受了LTSP，其余114例被分配到LT组。移植后1个月内，LTSP组的术后感染率明显高于LT组。两组在病原体详情和总体存活率方面无明显差异。在多变量分析中，SP、术后第3天（POD）中性粒细胞与淋巴细胞比值（NLR）、POD 7 NLR和POD 7血红蛋白（HGB）是术后感染的独立风险因素：LTSP会增加术后短期感染的风险，术后NLR可作为感染的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.