Pupillary responses for social versus non-social stimuli in autism: A systematic review and meta-analysis

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2024-09-03 DOI:10.1016/j.neubiorev.2024.105872

Giulia Stefanelli , Miriam Paola Pili , Giulia Crifaci , Elena Capelli , Carolina Beretta , Elena Maria Riboldi , Lucia Billeci , Chiara Cantiani , Massimo Molteni , Valentina Riva

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引用次数: 0

Abstract

Pupillometry has gained attention as a valuable tool for assessing autonomic nervous system activity and studying phasic changes in pupil size to comprehend underlying neurocognitive mechanisms. However, knowledge regarding pupillary responses to social processing in autism is limited. We conducted a systematic review and meta-analysis, examining research studies on pupil size changes that compare social and non-social stimuli in autism. Electronic searches were performed for articles up to September 2023 and relevant studies were evaluated following PRISMA guidelines. Out of 284 articles screened, 14 studies were eligible for systematic review. The results indicated that non-autistic individuals showed larger pupil size for social compared to non-social stimuli (g = 0.54; 95 % CI [0.25, 0.82]), whereas autistic individuals seemed to exhibit no differences between the two conditions. However, high heterogeneity was observed between studies in autistic populations, compromising interpretability. Despite such limitations, pupillary responses may constitute an objective physiological marker of social processing in autism. This review emphasizes the need for further investigations into pupillary responses in autism across different life stages.

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自闭症患者对社交与非社交刺激的瞳孔反应：系统回顾与荟萃分析。

瞳孔测量法是评估自律神经系统活动和研究瞳孔大小阶段性变化以了解潜在神经认知机制的重要工具，因而备受关注。然而，有关自闭症患者瞳孔对社交处理的反应的知识却很有限。我们对自闭症患者的瞳孔大小变化进行了系统回顾和荟萃分析，考察了比较社交刺激和非社交刺激的瞳孔大小变化研究。我们对截至 2023 年 9 月的文章进行了电子检索，并按照 PRISMA 指南对相关研究进行了评估。在筛选出的 284 篇文章中，有 14 项研究符合系统综述的条件。结果表明，与非社交刺激相比，非自闭症患者对社交刺激表现出更大的瞳孔（g = 0.54; 95% CI [0.25 0.82]），而自闭症患者在这两种情况下似乎没有表现出差异。然而，在自闭症人群中观察到的不同研究之间存在很大的异质性，这影响了研究的可解释性。尽管存在这些局限性，瞳孔反应仍可作为自闭症患者社交处理过程的客观生理标记。本综述强调有必要进一步研究自闭症患者在不同生命阶段的瞳孔反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.