Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biochemistry & Cell Biology Pub Date : 2024-09-03 DOI:10.1016/j.biocel.2024.106650

Qiaomin Wu , Yanli Wang , Jinfeng Liu, Xuanke Guan, Xing Chang, Zhiming Liu, Ruxiu Liu

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引用次数: 0

Abstract

Microtubules, complex cytoskeletal structures composed of tubulin proteins in eukaryotic cells, have garnered recent attention in cardiovascular research. Investigations have focused on the post-translational modifications of tubulin, including acetylation and detyrosination. Perturbations in microtubule homeostasis have been implicated in various pathological processes associated with cardiovascular diseases such as heart failure, ischemic heart disease, and arrhythmias. Thus, elucidating the intricate interplay between microtubule dynamics and cardiovascular pathophysiology is imperative for advancing preventive and therapeutic strategies. Several natural compounds have been identified to potentially modulate microtubules, thereby exerting regulatory effects on cardiovascular diseases. This review synthesizes current literature to delineate the roles of microtubules in cardiovascular diseases and assesses the potential of natural compounds in microtubule-targeted therapies.

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微管与心血管疾病：洞察病理学和治疗策略》。

微管是真核细胞中由微管蛋白组成的复杂细胞骨架结构，近年来在心血管研究中备受关注。研究重点是微管蛋白的翻译后修饰，包括乙酰化和脱酪氨酸化。微管平衡紊乱与心血管疾病（如心力衰竭、缺血性心脏病和心律失常）的各种病理过程有关。因此，阐明微管动力学与心血管病理生理学之间错综复杂的相互作用对于推进预防和治疗策略至关重要。目前已发现几种天然化合物有可能调节微管，从而对心血管疾病产生调节作用。这篇综述综述了目前的文献，描述了微管在心血管疾病中的作用，并评估了天然化合物在微管靶向疗法中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Biochemistry & Cell Biology 生物-生化与分子生物学

CiteScore

8.10

自引率

0.00%

发文量

124

审稿时长

19 days

期刊介绍： IJBCB publishes original research articles, invited reviews and in-focus articles in all areas of cell and molecular biology and biomedical research. Topics of interest include, but are not limited to: -Mechanistic studies of cells, cell organelles, sub-cellular molecular pathways and metabolism -Novel insights into disease pathogenesis -Nanotechnology with implication to biological and medical processes -Genomics and bioinformatics