Autoimmune Hashimoto's Disease and Feminization Level-Testing the Immunocompetence Hypothesis.

IF 1.1 4区 心理学 Q4 PSYCHOLOGY, EXPERIMENTAL
Malwina Goździk, Agnieszka Żelaźniewicz, Judyta Nowak-Kornicka, Katarzyna Pawłowska-Seredyńska, Wioleta Umławska, Bogusław Pawłowski
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Abstract

Morphological femininity depends mainly on estrogen levels at puberty and is perceived as a cue of a woman's biological condition. Due to the immunostimulant properties of estradiol, estradiol-dependent feminine traits are expected to be positively related to immunity. However, heightened immunity in women may increase the risk of autoimmune disease, thus the relationship between femininity and immune quality may be complex. This study aimed to assess the relationship between morphological femininity and both the occurrence and severity of Hashimoto thyroiditis (HT) in women of reproductive age. Moreover, 95 women with HT and 84 without HT (all between 20 and 37 years) participated in the study. Morphological femininity was assessed based on somatic measurements of sexually dimorphic traits (2D:4D ratio, WHR, breast size, facial sexual dimorphism). The occurrence and severity of HT were assessed by serum TPOAb levels. The results showed that only the 2D:4D ratio of the right hand was higher in the HT group, indicating higher femininity in these women. However, there was also a positive relationship between facial femininity and TPOAb level in women with HT, indicating a higher severity of the disease. The results suggest that prenatal and pubertal exposure to estrogens may increase the probability or severity of autoimmune diseases in adulthood, but the relationship is tentative.

自身免疫性桥本氏病与女性化水平--检验免疫能力假说。
形态上的女性特质主要取决于青春期的雌激素水平,并被视为女性生理状况的线索。由于雌二醇具有免疫刺激的特性,依赖雌二醇的女性特质预计与免疫力呈正相关。然而,女性免疫力的提高可能会增加患自身免疫性疾病的风险,因此女性特质与免疫质量之间的关系可能很复杂。本研究旨在评估育龄妇女的形态女性特质与桥本氏甲状腺炎(HT)的发生和严重程度之间的关系。此外,95名患有桥本氏甲状腺炎的女性和84名未患有桥本氏甲状腺炎的女性(年龄均在20至37岁之间)参与了这项研究。根据对性别二形特征(2D:4D 比率、WHR、乳房大小、面部性别二形性)的体格测量结果,对形态女性化进行了评估。通过血清 TPOAb 水平评估 HT 的发生和严重程度。结果显示,HT 组中只有右手的 2D:4D 比例较高,表明这些女性的女性化程度较高。然而,HT 女性患者的面部女性特质与 TPOAb 水平之间也存在正相关关系,这表明该疾病的严重程度更高。结果表明,产前和青春期暴露于雌激素可能会增加成年后患自身免疫性疾病的概率或严重程度,但这种关系是暂时的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Evolutionary Psychology
Evolutionary Psychology PSYCHOLOGY, EXPERIMENTAL-
CiteScore
2.20
自引率
6.70%
发文量
22
审稿时长
12 weeks
期刊介绍: Evolutionary Psychology is an open-access peer-reviewed journal that aims to foster communication between experimental and theoretical work on the one hand and historical, conceptual and interdisciplinary writings across the whole range of the biological and human sciences on the other.
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