Correlation Between the Fractional Amplitude of Low-Frequency Fluctuation and Cognitive Defects in Alzheimer's Disease.

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2024-09-02 DOI:10.3233/JAD-231040

Xuemei Zhang, Jie You, Qun Qao, Xinyang Qi, Jingping Shi, Junrong Li

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Abstract

Background: The fractional amplitude of low-frequency fluctuations (fALFFs) can detect spontaneous brain activity. However, the association between abnormal brain activity and cognitive function, amyloid protein (Aβ), and emotion in Alzheimer's disease (AD) patients remains unclear.

Objective: This study aimed to survey alterations in fALFF in different frequency bands and the relationship between abnormal brain activity, depressive mood, and cognitive function to determine the potential mechanism of AD.

Methods: We enrolled 34 AD patients and 32 healthy controls (HC). All the participants underwent resting-state magnetic resonance imaging, and slow-4 and slow-5 fALFF values were measured. Subsequently, the study determined the correlation of abnormal brain activity with mood and cognitive function scores.

Results: AD patients revealed altered mfALFF values in the slow-5 and slow-4 bands. In the slow-4 band, the altered mfALFF regions were the right cerebellar crus I, right inferior frontal orbital gyrus (IFOG), right supramarginal gyrus, right precuneus, angular gyrus, and left middle cingulate gyrus. Elevated mfALFF values in the right IFOG were negatively associated with Montreal Cognitive Assessment scores, Boston Naming Test, and Aβ1-42 levels. The mfALFF value of the AD group was lower than the HC group in the slow-5 band, primarily within the right inferior parietal lobule and right precuneus.

Conclusions: Altered mfALFF values in AD patients are linked with cognitive dysfunction. Compared with HCs, Aβ1-42 levels in AD patients are related to abnormal IFOG activity. Therefore, mfALFF could be a potential biomarker of AD.

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低频波动分幅与阿尔茨海默病认知缺陷之间的相关性

背景：低频波动分数振幅（fALFFs）可以检测自发的大脑活动。然而，阿尔茨海默病（AD）患者的异常脑活动与认知功能、淀粉样蛋白（Aβ）和情绪之间的关系仍不清楚：本研究旨在调查不同频段 fALFF 的改变以及异常脑活动、抑郁情绪和认知功能之间的关系，以确定 AD 的潜在机制：我们招募了34名AD患者和32名健康对照组（HC）。所有参与者都接受了静息态磁共振成像，并测量了慢4和慢5 fALFF值。随后，研究确定了异常大脑活动与情绪和认知功能评分的相关性：结果：AD 患者的慢-5 和慢-4 波段的 mfALFF 值发生了改变。在慢-4波段，mfALFF发生改变的区域是右侧小脑嵴I、右侧额眶下回（IFOG）、右侧边际上回、右侧楔前回、角回和左侧扣带回中部。右侧 IFOG 的 mfALFF 值升高与蒙特利尔认知评估得分、波士顿命名测试和 Aβ1-42 水平呈负相关。注意力缺失症组的 mfALFF 值在慢-5 波段低于注意力缺失症组，主要是在右侧下顶叶和右侧楔前叶：结论：AD患者mfALFF值的改变与认知功能障碍有关。与普通人相比，AD 患者的 Aβ1-42 水平与 IFOG 活动异常有关。因此，mfALFF可能是AD的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.

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