Association of Plastic Exposure with Cognitive Function Among Chinese Older Adults.

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2024-01-01 DOI:10.3233/JAD-240746

Yongbin Zhu, Yueping Wu, Liping Shi, Yue Yang, Yanrong Wang, Degong Pan, Shulan He, Liqun Wang, Jiangping Li

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引用次数: 0

Abstract

Background: The widespread exposure to plastic products and the increasing number of individuals with cognitive impairments have imposed a heavy burden on society.

Objective: This study aims to investigate the relationship between plastic product exposure in daily life and cognitive function in older Chinese individuals.

Methods: Data were obtained from the 2023 Ningxia Older Psychological Health Cohort, comprising 4045 participants aged 60 and above. Cognitive function was assessed using the Mini-Mental State Examination scale. A population-based plastic exposure questionnaire was used to calculate plastic exposure scores (PES). Binary logistic regression was employed to analyze the relationship between PES and cognitive function, while restricted cubic splines were used to examine the dose-response relationship between PES and cognitive function. Latent profile analysis (LPA) was employed to explore the potential patterns of plastic exposure, and logistic regression was used to investigate the relationship between different exposure patterns and cognitive function. A linear regression model was utilized to investigate the relationship between PES and different dimensions of cognitive function.

Results: Among the 4045 participants, 1915 individuals were assessed with mild cognitive impairment (MCI). After adjusting for all covariates, PES (OR = 1.04, 95% CI 1.02-1.06) was significantly associated with the risk of MCI and exhibited a dose-response relationship. LPA identified two potential categories of plastic exposure, with a higher risk of MCI observed in the group using plastic utensils.

Conclusions: This study indicates a positive correlation between plastic exposure levels and MCI risk, particularly among individuals who frequently use plastic tableware.

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塑料暴露与中国老年人认知功能的关系

背景：塑料产品的广泛接触和认知障碍患者的不断增加给社会带来了沉重负担：塑料制品的广泛接触和认知障碍患者的不断增加给社会带来了沉重的负担：本研究旨在探讨日常生活中塑料制品暴露与中国老年人认知功能之间的关系：研究数据来自 2023 年宁夏老年心理健康队列，其中包括 4045 名 60 岁及以上的参与者。认知功能采用迷你精神状态检查量表进行评估。采用基于人群的塑料暴露问卷计算塑料暴露得分（PES）。二元逻辑回归用于分析 PES 与认知功能之间的关系，而限制性三次样条则用于检验 PES 与认知功能之间的剂量-反应关系。采用潜特征分析（LPA）来探索潜在的塑料暴露模式，并采用逻辑回归来研究不同暴露模式与认知功能之间的关系。利用线性回归模型研究了PES与认知功能不同维度之间的关系：在 4045 名参与者中，有 1915 人被评估为轻度认知障碍（MCI）。在对所有协变量进行调整后，PES（OR = 1.04，95% CI 1.02-1.06）与 MCI 风险显著相关，并呈现出剂量反应关系。LPA确定了两种潜在的塑料接触类别，使用塑料器皿的人群患MCI的风险较高：这项研究表明，塑料暴露水平与 MCI 风险之间存在正相关，尤其是在经常使用塑料餐具的人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.