Lautropia mirabilis sepsis in immunodeficiency: first report and genomic features.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2024-09-06 DOI:10.1007/s15010-024-02388-6

Svea Genseke, Mirjeta Berisha, Aljoscha Teerstegen, Björn Meyer, Achim J Kaasch, Jacqueline Färber, Enrico Schalk, Andreas E Zautner, Torben Esser, Sascha Kahlfuß

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引用次数: 0

Abstract

Purpose: Lautropia mirabilis is a Gram-negative, facultative anaerobic coccus, which has been detected mainly in respiratory sites of immunodeficient patients suffering from HIV or cystic fibrosis. To date, knowledge about the pathogenicity of L. mirabilis is spare due to the small numbers of documented cases.

Methods: We present a literature review and report the case of a 39-year-old female diagnosed with common variable immunodeficiency (CVID) with IgG and IgA deficiency suffering from a sepsis with L. mirabilis. As no fully closed L. mirabilis genome besides the type strain was available to date, we additionally performed complete genome sequencing of L. mirabilis.

Results: The patient was admitted to our hospital with recurrent episodes of fever. Here, we detected L. mirabilis in two different blood cultures. The bacterium was tested susceptible to and treated with meropenem. As the origin of L. mirabilis sepsis, we observed an active periodontitis likely due to impaired IgA levels and mucosal insufficiency as a consequence of CVID. Whole genome sequencing of L. mirabilis revealed several genes important for host cell invasion and intracellular survival of the pathogen.

Conclusions: Our case highlights the importance of L. mirabilis in immunocompromised patients also in other compartments than the respiratory tract.

Abstract Image

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免疫缺陷病中的奇异鹦鹉热败血症：首次报告和基因组特征。

目的：奇异变形杆菌（Lautropia mirabilis）是一种革兰氏阴性兼性厌氧球菌，主要在艾滋病病毒感染者或囊性纤维化患者的呼吸道部位被发现。迄今为止，由于记录在案的病例较少，有关 L. mirabilis 致病性的知识还很匮乏：我们对文献进行了回顾，并报告了一例39岁女性因奇异变形杆菌败血症而被诊断为常见变异性免疫缺陷症（CVID）并伴有IgG和IgA缺乏症的病例。由于迄今为止除模式菌株外还没有完全封闭的奇异变形杆菌基因组，因此我们对奇异变形杆菌进行了完整的基因组测序：结果：患者因反复发烧入住我院。我们在两种不同的血液培养物中检测到了奇异变形杆菌。经检测，该细菌对美罗培南敏感并接受了治疗。作为奇异变形杆菌败血症的起源，我们观察到活动性牙周炎可能是由于 IgA 水平受损和 CVID 导致的粘膜功能不全引起的。奇异变形杆菌的全基因组测序发现了几个对宿主细胞入侵和病原体在细胞内存活非常重要的基因：结论：我们的病例凸显了奇异变形杆菌在免疫力低下患者中的重要性，它也存在于呼吸道以外的其他部位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.