Naturally Occurring Food Chemical Components and Extraintestinal and Gastrointestinal Symptoms in Adults: A Systematic Review

IF 6.3 2区医学 Q1 ALLERGY

Clinical and Experimental Allergy Pub Date : 2024-09-05 DOI:10.1111/cea.14561

Zoe Cooke, Kathryn Lynam, Caroline Tuck, Gina Louise Trakman

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引用次数: 0

Abstract

Objective

This systematic review aims to synthesise existing literature to examine the relationship between natural food chemical components and reported symptoms.

Design

A systematic literature review was completed. Databases CINAHL (Ebscohost), Medline (Ovid), Scopus, Informit Health and Google Scholar were searched to identify relevant articles. The population included human studies of adults (≥17 years) and excluded those with IgE-mediate food allergies. Studies examining food chemical components or ‘food chemical elimination diets’ and symptoms were included. Data was synthesised based on clinical conditions and specific food chemical components examined. The risk of bias was assessed using the Academy of Nutrition and Dietetics ‘Quality Criteria Checklist: Primary Research’.

Results

Of the 1659 articles retrieved, 21 met inclusion criteria. This included eight randomised controlled trials, four non-randomised controlled trials, four cohort studies with placebo-controlled challenge, one prospective cohort study, three cross sectional cohort studies, one case–controlled study. Available studies support the role of a low-histamine diet for symptoms in chronic urticaria and low-salicylate diet for reducing sino-nasal symptoms in aspirin exacerbated respiratory disease and chronic rhinosinusitis and/or asthma. While further evidence is needed to verify the role of glutamate in respiratory, pain, asthma and gastrointestinal symptoms.

Conclusions

Food chemical elimination diets may improve condition-specific symptoms across the adult cohorts outlined within this review, with the strongest evidence to support the role of a low-histamine diet for management of symptoms in chronic urticaria and a low-salicylate diet in aspirin exacerbated respiratory disease and/or asthma. Further well-designed trials are needed to elucidate the effect of specific natural food chemical components on symptoms.

Trial Registration

Systematic review number: CRD42022322511.

Abstract Image

查看原文本刊更多论文

天然食物化学成分与成人肠外症状和胃肠道症状：系统综述。

目的：本系统综述旨在综合现有文献，研究天然食物化学成分与报告症状之间的关系：本系统综述旨在综合现有文献，研究天然食品化学成分与报告症状之间的关系：设计：完成系统性文献综述。检索了 CINAHL (Ebscohost)、Medline (Ovid)、Scopus、Informit Health 和 Google Scholar 等数据库，以确定相关文章。研究对象包括成年人（≥17 岁），但不包括 IgE 媒介型食物过敏者。还包括对食物化学成分或 "消除食物化学成分饮食 "和症状的研究。根据临床情况和所研究的特定食物化学成分对数据进行综合。采用营养与饮食科学院的 "质量标准检查表 "对偏倚风险进行了评估：结果：在检索到的 1659 篇文章中，有 21 篇符合纳入标准。其中包括 8 项随机对照试验、4 项非随机对照试验、4 项安慰剂对照挑战队列研究、1 项前瞻性队列研究、3 项横断面队列研究和 1 项病例对照研究。现有研究支持低组胺饮食对慢性荨麻疹症状的作用，以及低水杨酸饮食对减轻阿司匹林加重的呼吸道疾病和慢性鼻炎和/或哮喘的鼻鼻症状的作用。尽管还需要进一步的证据来验证谷氨酸盐在呼吸道、疼痛、哮喘和胃肠道症状中的作用：本综述概述的成人组群中，食物化学物排除饮食可改善特定症状，其中最有力的证据支持低组胺饮食对慢性荨麻疹症状的控制作用，以及低水杨酸饮食对阿司匹林加重的呼吸道疾病和/或哮喘的作用。要阐明特定天然食物化学成分对症状的影响，还需要进一步设计完善的试验：系统综述编号CRD42022322511。

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来源期刊

Clinical and Experimental Allergy 医学-过敏

CiteScore

10.40

自引率

9.80%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical & Experimental Allergy strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading authorities in their field. In response to the increasing number of quality submissions, since 1996 the journals size has increased by over 30%. Clinical & Experimental Allergy is essential reading for allergy practitioners and research scientists with an interest in allergic diseases and mechanisms. Truly international in appeal, Clinical & Experimental Allergy publishes clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part.