5-Fluorouracil-loaded green chitosan nanoparticles/ guar gum nanocomposite hydrogel in controlled drug delivery

IF 2.4 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
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Abstract

In recent years nanotechnologies have been applied to human health with promising results, especially in the field of drug delivery. Polymeric nanoparticles (NPs) have garnered much importance in controlled drug delivery owing to their size. Chitosan (Cs) is a well-recognized biopolymer and Cs NPs have been widely explored in drug delivery. Nonetheless, reports pertaining to green synthesis of Cs NPs are scarce. Thus, in this study, green synthesis of Cs NPs was accomplished from raw mango peel extract. Spherical Cs NPs with positively charged surface of 33.4 mV was accomplished by this process. Cs NPs, in varied content, were integrated in a guar gum network matrix resulting in a nanocomposite hydrogel. The mechanical and thermal stability of the hydrogel improved upon addition of Cs NPs. The hydrogel exhibited smart swelling, good antioxidant and anti-inflammatory propensities. Cs NPs encapsulating 5-Fluorouracil demonstrated a controlled release drug profile in the colorectum and the kinetics implied the anomalous nature of drug release mechanism. The exposure of the drug-loaded nanocomposite hydrogel displayed improved anticancer effects in HT-29 colon cancer cells. Taken altogether, this study puts forth the greater efficacy of Cs NPs in controlled drug delivery for anticancer therapy.

Abstract Image

5-氟尿嘧啶负载的绿色壳聚糖纳米颗粒/瓜尔胶纳米复合水凝胶在控制给药中的应用
近年来,纳米技术已被应用于人类健康领域,并取得了可喜的成果,尤其是在给药领域。高分子纳米粒子(NPs)因其尺寸小,在控制药物递送方面备受重视。壳聚糖(Cs)是一种公认的生物聚合物,Cs NPs 在给药方面也得到了广泛的探索。然而,有关 Cs NPs 绿色合成的报道却很少。因此,本研究利用生芒果皮提取物完成了 Cs NPs 的绿色合成。通过该工艺,获得了表面正电荷为 33.4 mV 的球形铯 NPs。不同含量的铯 NPs 被整合到瓜尔胶网络基质中,形成了一种纳米复合水凝胶。添加铯 NPs 后,水凝胶的机械稳定性和热稳定性都得到了改善。该水凝胶具有良好的溶胀性、抗氧化性和抗炎性。封装了 5-氟尿嘧啶的铯 NPs 在结肠直肠中表现出药物控释特性,其动力学表明药物释放机制具有反常性。药物负载纳米复合水凝胶在 HT-29 结肠癌细胞中的暴露显示出更好的抗癌效果。总之,这项研究提出了铯纳米粒子在抗癌治疗中的更大的药物控制释放功效。
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来源期刊
Carbohydrate Research
Carbohydrate Research 化学-生化与分子生物学
CiteScore
5.00
自引率
3.20%
发文量
183
审稿时长
3.6 weeks
期刊介绍: Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".
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