Liver enzyme levels in adolescents with obesity and insulin resistance: a propensity score matching analysis.

IF 0.6 Q4 PEDIATRICS

Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI:10.24875/BMHIM.23000161

Miguel A Villasis-Keever, Jessie N Zurita-Cruz, Karla D Nava-Sanchez, Aly Sugei Barradas-Vázquez, Ana L López-Beltran, Mireya E Espíritu-Díaz, Martha A Delgadillo-Ruano

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引用次数: 0

Abstract

Background: Elevated liver enzyme levels have been associated with metabolic syndrome in both obese and non-obese pediatric populations. This study aims to compare the serum liver enzyme levels in obese adolescents with and without insulin resistance (IR).

Methods: A cross-sectional analysis was conducted involving obese adolescents aged 10-18. We assessed somatometry, serum insulin levels, lipid profiles, and liver enzymes (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma-glutamyl transferase [GGT]). Statistical differences between groups were evaluated using Student's t-test or the Chi-squared test, with IR (wIR) status matched by propensity scores based on body mass index (BMI) z-scores.

Results: The study included 365 adolescents with obesity, 229 wIR, and 136 without (woIR). Before matching, the wIR group had a significantly higher BMI z-score (2.21 vs. 2.14, p = 0.032). After matching for BMI z-scores (n = 122 each group), the wIR group displayed significantly higher levels of AST (32.3 vs. 24.7, p < 0.001) and ALT (42.4 vs. 30.9, p < 0.001), but no significant differences were observed in GGT levels (37.4 vs. 32.5, p = 0.855).

Conclusion: Obese adolescent's wIR exhibit higher serum ALT and AST levels, suggesting that altered AST is a potential risk factor for IR.

查看原文本刊更多论文

肥胖和胰岛素抵抗青少年的肝酶水平：倾向得分匹配分析。

背景：在肥胖和非肥胖儿科人群中，肝酶水平升高都与代谢综合征有关。本研究旨在比较有胰岛素抵抗（IR）和无胰岛素抵抗（IR）的肥胖青少年的血清肝酶水平：我们对 10-18 岁肥胖青少年进行了横断面分析。我们评估了体格测量、血清胰岛素水平、血脂概况和肝酶（天冬氨酸氨基转移酶[AST]、丙氨酸氨基转移酶[ALT]和γ-谷氨酰转移酶[GGT]）。采用学生 t 检验或卡方检验评估组间的统计差异，IR（wIR）状态与基于体重指数（BMI）z-分数的倾向得分相匹配：研究对象包括 365 名肥胖青少年、229 名有 IR 青少年和 136 名无 IR 青少年（woIR）。在匹配前，woIR 组的 BMI z-score 明显更高（2.21 vs. 2.14，p = 0.032）。根据体重指数 z 值进行匹配后（每组 122 人），wIR 组的谷草转氨酶（AST）（32.3 vs. 24.7，p < 0.001）和谷丙转氨酶（ALT）（42.4 vs. 30.9，p < 0.001）水平明显较高，但谷草转氨酶（GGT）水平（37.4 vs. 32.5，p = 0.855）无明显差异：结论：肥胖青少年 IR 患者的血清谷丙转氨酶（ALT）和谷草转氨酶（AST）水平较高，表明谷丙转氨酶（AST）的变化是 IR 的潜在风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Boletín médico del Hospital Infantil de México PEDIATRICS-

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Boletín Médico del Hospital Infantil de México is a bimonthly publication edited by the Hospital Infantil de México Federico Gómez. It receives unpublished manuscripts, in English or Spanish, relating to paediatrics in the following areas: biomedicine, clinical, public health, clinical epidemology, health education and clinical ethics. Articles can be original research articles, in-depth or systematic reviews, clinical cases, clinical-pathological cases, articles about public health, letters to the editor or editorials (by invitation).