Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer

IF 4.4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemistry international Pub Date : 2024-09-03 DOI:10.1016/j.neuint.2024.105853

Janani Ramesh , Raja Mohan Gopalakrishnan , Tuan Hoang Anh Nguyen , Soak-Kuan Lai , Hoi-Yeung Li , Pok-Son Kim , Arne Kutzner , Noriko Inoue , Klaus Heese

引用次数: 0

Abstract

Family with sequence similarity 72 (FAM72) is a protein-coding gene family located on chromosome 1 in humans, uniquely featuring four paralogs: FAM72A, FAM72B, FAM72C, and FAM72D. While FAM72's presence as a gene pair with the SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) is intriguing, its functional roles, particularly in neural stem cells, remain incompletely understood. This review explores the distinct characteristics of FAM72, shedding light on its expression patterns, potential roles in cell cycle regulation, stem cell renewal and implications in neurogenesis and tumorigenesis.

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解密 FAM72 基因家族的分子景观：对干细胞生物学和癌症的影响

序列相似性家族 72（FAM72）是位于人类 1 号染色体上的一个蛋白质编码基因家族，有四个独特的旁系亲属：FAM72A、FAM72B、FAM72C 和 FAM72D。虽然 FAM72 与 SLIT-ROBO Rho GTPase-activating protein 2（SRGAP2）是一对基因，但其功能作用，尤其是在神经干细胞中的功能作用，仍不完全清楚。这篇综述探讨了FAM72的独特特征，揭示了它的表达模式、在细胞周期调控、干细胞更新中的潜在作用以及在神经发生和肿瘤发生中的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurochemistry international 医学-神经科学

CiteScore

8.40

自引率

2.40%

发文量

128

审稿时长

37 days

期刊介绍： Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.