Monascus pigment-protected bone marrow-derived stem cells for heart failure treatment

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2024-09-04 DOI:10.1016/j.bioactmat.2024.08.038

Tian Yue , Wentai Zhang , Haifeng Pei , Dunzhu Danzeng , Jian He , Jiali Yang , Yong Luo , Zhen Zhang , Shiqiang Xiong , Xiangbo Yang , Qisen Ji , Zhilu Yang , Jun Hou

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引用次数: 0

Abstract

Mesenchymal stem cells (MSCs) have demonstrated significant therapeutic potential in heart failure (HF) treatment. However, their clinical application is impeded by low retention rate and low cellular activity of MSCs caused by high inflammatory and reactive oxygen species (ROS) microenvironment. In this study, monascus pigment (MP) nanoparticle (PPM) was proposed for improving adverse microenvironment and assisting in transplantation of bone marrow-derived MSCs (BMSCs). Meanwhile, in order to load PPM and reduce the mechanical damage of BMSCs, injectable hydrogels based on Schiff base cross-linking were prepared. The PPM displays ROS-scavenging and macrophage phenotype-regulating capabilities, significantly enhancing BMSCs survival and activity in HF microenvironment. This hydrogel demonstrates superior biocompatibility, injectability, and tissue adhesion. With the synergistic effects of injectable, adhesive hydrogel and the microenvironment-modulating properties of MP, cardiac function was effectively improved in the pericardial sac of rats. Our results offer insights into advancing BMSCs-based HF therapies and their clinical applications.

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用于治疗心力衰竭的骨髓来源干细胞

间充质干细胞（MSCs）在治疗心力衰竭（HF）方面具有显著的治疗潜力。然而，由于高炎症性和活性氧（ROS）微环境导致间充质干细胞存留率低和细胞活性低，阻碍了间充质干细胞的临床应用。本研究提出了单层色素（MP）纳米颗粒（PPM）来改善不良微环境，并协助骨髓间充质干细胞（BMSCs）的移植。同时，为了负载 PPM 并减少 BMSCs 的机械损伤，制备了基于席夫碱交联的可注射水凝胶。PPM 具有清除 ROS 和调节巨噬细胞表型的功能，能显著提高 BMSCs 在高频微环境中的存活率和活性。这种水凝胶具有良好的生物相容性、注射性和组织粘附性。在可注射、粘性水凝胶和 MP 微环境调节特性的协同作用下，大鼠心包囊的心脏功能得到了有效改善。我们的研究结果为推进基于 BMSCs 的高频疗法及其临床应用提供了启示。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.