Effect of timing of umbilical cord clamping and birth on fetal to neonatal transition: OpenModelica-based virtual simulator-based approach

IF 5.3 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Edgar Hernando Sepúlveda-Oviedo , Leonardo Enrique Bermeo Clavijo , Luis Carlos Méndez-Córdoba
{"title":"Effect of timing of umbilical cord clamping and birth on fetal to neonatal transition: OpenModelica-based virtual simulator-based approach","authors":"Edgar Hernando Sepúlveda-Oviedo ,&nbsp;Leonardo Enrique Bermeo Clavijo ,&nbsp;Luis Carlos Méndez-Córdoba","doi":"10.1016/j.bbe.2024.08.008","DOIUrl":null,"url":null,"abstract":"<div><p>The transition from fetal to newborn condition involves complex physiological adaptations for extrauterine life. A crucial event in this process is <em>the clamping of the umbilical cord</em>, which can be categorized as immediate or delayed. The type of clamping significantly influences the hemodynamics of the newborn. In this study, we developed a simulator based on existing cardiovascular models to better understand this practice. The simulator covers the period from late gestation to 24 h after birth and faithfully reproduces flow patterns observed in real-life situations (as evaluated by clinical specialists), considering factors such as the timing of cord clamping and the altitude of the birth location. It also reproduces blood pressure values reported in clinical data. Under similar conditions, the simulation results indicate that delayed cord clamping leads to increased oxygen concentration and improved blood volume compared to immediate cord clamping. Delayed cord clamping also had a positive impact on sustained placental respiration. Furthermore, this study provides further evidence that umbilical cord clamping should be based on physiological criteria rather than predefined time intervals.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 3","pages":"Pages 716-730"},"PeriodicalIF":5.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000615/pdfft?md5=e5a6695a259ebc59fa93e072a4230232&pid=1-s2.0-S0208521624000615-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biocybernetics and Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0208521624000615","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

Abstract

The transition from fetal to newborn condition involves complex physiological adaptations for extrauterine life. A crucial event in this process is the clamping of the umbilical cord, which can be categorized as immediate or delayed. The type of clamping significantly influences the hemodynamics of the newborn. In this study, we developed a simulator based on existing cardiovascular models to better understand this practice. The simulator covers the period from late gestation to 24 h after birth and faithfully reproduces flow patterns observed in real-life situations (as evaluated by clinical specialists), considering factors such as the timing of cord clamping and the altitude of the birth location. It also reproduces blood pressure values reported in clinical data. Under similar conditions, the simulation results indicate that delayed cord clamping leads to increased oxygen concentration and improved blood volume compared to immediate cord clamping. Delayed cord clamping also had a positive impact on sustained placental respiration. Furthermore, this study provides further evidence that umbilical cord clamping should be based on physiological criteria rather than predefined time intervals.

Abstract Image

夹断脐带和分娩时间对胎儿到新生儿转变的影响:基于 OpenModelica 虚拟模拟器的方法
从胎儿状态到新生儿状态的转变涉及对宫外生活的复杂生理适应。这一过程中的一个关键事件是脐带夹紧,可分为立即夹紧和延迟夹紧。脐带夹的类型对新生儿的血液动力学有很大影响。在这项研究中,我们在现有心血管模型的基础上开发了一个模拟器,以便更好地理解这种做法。该模拟器涵盖了从妊娠晚期到新生儿出生后 24 小时这段时间,忠实再现了在实际情况下观察到的血流模式(由临床专家评估),并考虑了脐带夹闭的时间和出生地的海拔高度等因素。它还再现了临床数据中报告的血压值。在类似条件下,模拟结果表明,与立即夹闭脐带相比,延迟夹闭脐带可提高氧气浓度,改善血容量。延迟脐带夹闭对胎盘持续呼吸也有积极影响。此外,这项研究还进一步证明,脐带钳夹应基于生理标准,而不是预先确定的时间间隔。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
16.50
自引率
6.20%
发文量
77
审稿时长
38 days
期刊介绍: Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信