Bioactive sphingolipids as emerging targets for signal transduction in cancer development

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Wentao Jia , Jiaying Yuan , Jinbo Zhang , Shu Li , Wanfu Lin , Binbin Cheng
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引用次数: 0

Abstract

Sphingolipids, crucial components of cellular membranes, play a vital role in maintaining cellular structure and signaling integrity. Disruptions in sphingolipid metabolism are increasingly implicated in cancer development. Key bioactive sphingolipids, such as ceramides, sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P), and glycosphingolipids, profoundly impact tumor biology. They influence the behavior of tumor cells, stromal cells, and immune cells, affecting tumor aggressiveness, angiogenesis, immune modulation, and extracellular matrix remodeling. Furthermore, abnormal expression of sphingolipids and their metabolizing enzymes modulates the secretion of tumor-derived extracellular vesicles (TDEs), which are key players in creating an immunosuppressive tumor microenvironment, remodeling the extracellular matrix, and facilitating oncogenic signaling within in situ tumors and distant pre-metastatic niches (PMNs). Understanding the role of sphingolipids in the biogenesis of tumor-derived extracellular vesicles (TDEs) and their bioactive contents can pave the way for new biomarkers in cancer diagnosis and prognosis, ultimately enhancing comprehensive tumor treatment strategies.

生物活性鞘脂是癌症发展过程中信号转导的新目标。
鞘磷脂是细胞膜的重要组成部分,在维持细胞结构和信号完整性方面发挥着重要作用。鞘脂代谢紊乱与癌症发展的关系日益密切。关键的生物活性鞘脂,如神经酰胺、鞘氨醇-1-磷酸(S1P)、神经酰胺-1-磷酸(C1P)和糖鞘脂,会对肿瘤生物学产生深远影响。它们影响肿瘤细胞、基质细胞和免疫细胞的行为,影响肿瘤的侵袭性、血管生成、免疫调节和细胞外基质重塑。此外,鞘磷脂及其代谢酶的异常表达会调节肿瘤源性细胞外泡(TDEs)的分泌,而TDEs是创造免疫抑制性肿瘤微环境、重塑细胞外基质以及促进原位肿瘤和远处转移前壁龛(PMNs)内致癌信号传导的关键因素。了解鞘脂在肿瘤源性细胞外泡(TDEs)的生物生成过程中的作用及其生物活性成分,可以为癌症诊断和预后的新生物标记物铺平道路,最终提高肿瘤综合治疗策略的水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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