The evolving landscape of immunohistochemistry in cervical and uterine carcinoma in gynecologic oncology: current status and future directions.

IF 2 Q2 OBSTETRICS & GYNECOLOGY

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-09-04 DOI:10.5468/ogs.24120

Sumedha Gupta, Sana Ahuja, Dheer Singh Kalwaniya

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引用次数: 0

Abstract

Immunohistochemistry (IHC) has become an indispensable tool in routine gynecological pathology, particularly with the advancements in molecular understanding and histological classification of gynecological cancers. This evolution has led to new immunostainings for diagnostic and classification purposes. This review describes the diagnostic utility of IHC in gynecological neoplasms, drawing insights from literature reviews, personal experiences, and research findings. It delves into the application of IHC in resolving morphologically equivocal cases, emphasizing its role in achieving an accurate diagnosis. The selection of appropriate immunomarkers for common scenarios encountered in gynecological pathology aids pathologists in navigating complex cases. Specifically, we focus on cervical and endometrial malignancies, elucidating the molecular rationale behind the use of specific immunohistochemical markers. An updated overview of essential immunohistochemical markers provides knowledge for precise diagnosis and classification of gynecological cancers. This review serves as a valuable resource for clinicians and researchers involved in the management and study of gynecological malignancies, facilitating improved patient care and outcomes.

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妇科肿瘤学中宫颈癌和子宫癌免疫组化的演变：现状和未来方向。

免疫组化（IHC）已成为常规妇科病理学中不可或缺的工具，尤其是随着对妇科癌症的分子认识和组织学分类的进步。这种演变催生了用于诊断和分类的新型免疫染色。本综述从文献综述、个人经验和研究结果中汲取灵感，阐述了 IHC 在妇科肿瘤中的诊断作用。它深入探讨了 IHC 在解决形态不明确病例中的应用，强调了 IHC 在实现准确诊断中的作用。针对妇科病理学中常见的情况选择适当的免疫标记物有助于病理学家处理复杂的病例。我们特别关注宫颈和子宫内膜恶性肿瘤，阐明了使用特定免疫组化标记物的分子原理。对基本免疫组化标记物的最新概述为妇科癌症的精确诊断和分类提供了知识。这本综述是从事妇科恶性肿瘤管理和研究的临床医生和研究人员的宝贵资源，有助于改善患者护理和治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obstetrics and Gynecology Science Medicine-Obstetrics and Gynecology

CiteScore

3.80

自引率

15.80%

发文量

审稿时长

16 weeks

期刊介绍： Obstetrics & Gynecology Science (NLM title: Obstet Gynecol Sci) is an international peer-review journal that published basic, translational, clinical research, and clinical practice guideline to promote women’s health and prevent obstetric and gynecologic disorders. The journal has an international editorial board and is published in English on the 15th day of every other month. Submitted manuscripts should not contain previously published material and should not be under consideration for publication elsewhere. The journal has been publishing articles since 1958. The aim of the journal is to publish original articles, reviews, case reports, short communications, letters to the editor, and video articles that have the potential to change the practices in women''s health care. The journal’s main focus is the diagnosis, treatment, prediction, and prevention of obstetric and gynecologic disorders. Because the life expectancy of Korean and Asian women is increasing, the journal''s editors are particularly interested in the health of elderly women in these population groups. The journal also publishes articles about reproductive biology, stem cell research, and artificial intelligence research for women; additionally, it provides insights into the physiology and mechanisms of obstetric and gynecologic diseases.