Foetal outcome of Leptospira and Rickettsial infections during pregnancy: a systematic review.

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-12-03 DOI:10.1093/trstmh/trae053

Mallika Sengupta, Latha T, Soumitra Mandal, Kaushik Mukhopadhyay

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引用次数: 0

Abstract

Background: Leptospirosis and rickettsial infections are bacterial zoonoses prevalent in different geographical locations and presents with overlapping symptoms.

Objective: To identify foetal outcomes in pregnant women diagnosed with rickettsial infections, including scrub typhus and leptospirosis, along with their associated factors.

Methods: A comprehensive search was conducted in MEDLINE/PubMed, Scopus, CENTRAL (Cochrane), Web of Science, PsycINFO, Academic Search Premier, CINAHL, and Embase using defined search terms. Studies involving pregnant women with diagnosed leptospirosis and rickettsial infections, including scrub typhus, were selected. Two independent reviewers screened titles and abstracts using the Rayyan Web interface. Data extraction was performed in Microsoft Excel, with Zotero for reference management. Study quality was assessed using Joanna Briggs Institute Critical Appraisal tools. Data synthesis included narrative analysis.

Results: Fifty-four studies were included: 22 on scrub typhus, 14 on rickettsial infection, 16 on leptospirosis, and 2 on all three infections. Of 176 scrub typhus cases, 53 resulted in foetal loss and 3 in neonatal death. Among 38 rickettsial infection cases, 4 had foetal loss. Out of 63 leptospirosis cases, 13 experienced foetal loss. Six maternal deaths occurred due to scrub typhus and one due to Rocky Mountain spotted fever.

Conclusion: Leptospirosis and rickettsial infections, including scrub typhus, are important causes of pregnancy loss. Further research is needed to better understand and mitigate these risks in pregnant women.

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孕期钩端螺旋体和立克次体感染对胎儿的影响：系统综述。

背景：钩端螺旋体病和立克次体感染是流行于不同地区的细菌性人畜共患病，其症状相互重叠：目的：确定被诊断为立克次体感染（包括恙虫病和钩端螺旋体病）的孕妇的胎儿结局及其相关因素：方法：使用定义的检索词在MEDLINE/PubMed、Scopus、CENTRAL（Cochrane）、Web of Science、PsycINFO、Academic Search Premier、CINAHL和Embase中进行全面检索。筛选出的研究涉及确诊患有钩端螺旋体病和立克次体感染（包括恙虫病）的孕妇。两名独立审稿人使用 Rayyan Web 界面筛选标题和摘要。数据提取在 Microsoft Excel 中进行，并使用 Zotero 进行参考文献管理。使用乔安娜-布里格斯研究所的关键评估工具对研究质量进行评估。数据综合包括叙事分析：结果：共纳入 54 项研究：22项研究涉及恙虫病，14项研究涉及立克次体感染，16项研究涉及钩端螺旋体病，2项研究涉及所有三种感染。在176例恙虫病病例中，53例导致胎儿死亡，3例导致新生儿死亡。在 38 例立克次体感染病例中，4 例导致胎儿死亡。在 63 例钩端螺旋体病例中，有 13 例导致胎儿死亡。6名产妇死于恙虫病，1名产妇死于落基山斑疹热：结论：钩端螺旋体病和立克次体感染（包括恙虫病）是导致孕妇流产的重要原因。需要进一步开展研究，以更好地了解和降低孕妇的这些风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transactions of The Royal Society of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.00

自引率

9.10%

发文量

115

审稿时长

4-8 weeks

期刊介绍： Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.